Prolonged forearm ischemia attenuates endothelium-dependent vasodilatation and plasma nitric oxide metabolites in overweight middle-aged men
| Autor: | Jonathan Fulford, Sarah R. Jackman, Zainie Aboo Bakkar, Joanna L. Bowtell, Phillip E. Gates, Andrew M. Jones, Bert Bond |
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| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Male medicine.medical_specialty Physiology Ischemia Vasodilation Peroxiredoxin 2 030204 cardiovascular system & hematology medicine.disease_cause Nitric Oxide Nitric oxide 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Peroxiredoxin-2 Forearm Physiology (medical) Internal medicine medicine.artery Occlusion medicine Humans Orthopedics and Sports Medicine Brachial artery business.industry Forearm occlusion Public Health Environmental and Occupational Health Endothelial function General Medicine Middle Aged Overweight medicine.disease 030104 developmental biology medicine.anatomical_structure chemistry Cardiology Nitrite/nitrate Original Article Endothelium Vascular business Oxidative stress |
| Zdroj: | European Journal of Applied Physiology |
| ISSN: | 1439-6327 1439-6319 |
| Popis: | Purpose Repeated cycles of endothelial ischemia–reperfusion injury and the resulting respiratory burst contribute to the irreversible pathophysiology of vascular diseases, and yet, the effects of ischemia reperfusion on vascular function, oxidative stress, and nitric oxide (NO) bioavailability have not been assessed simultaneously. Therefore, this study sought to examine the effects of prolonged forearm occlusion and subsequent reperfusion on NO-dependent brachial artery endothelial function. Methods Flow-mediated dilatation was measured at baseline and 15, 30, and 45 min after 20-min forearm occlusion in 14 healthy, but physically inactive middle-aged men (53.7 ± 1.2 years, BMI: 28.1 ± 0.1 kg m−2). Venous blood samples collected from the occluded arm were analyzed for NO metabolites and markers of oxidative stress. Results FMD was significantly depressed after the prolonged occlusion compared to baseline, with a significant reduction 15-min post-occlusion (6.6 ± 0.7 to 2.9 ± 0.4%, p |
| Databáze: | OpenAIRE |
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