Helicobacter pylorieradication reduces platelet count in patients without idiopathic thrombocytopenic purpura

Autor:	Yasuyuki Arakawa, Yoshihiro Matsukawa, Shigemasa Sawada, Izumi Hayashi, Shigeaki Mizuno, Hanzo Kurosaka, Ryuichi Kurihara, Yoshihiro Hatta, Kimitoshi Kato, Maho Iwamoto
Rok vydání:	2007
Předmět:	medicine.medical_specialty Lansoprazole macromolecular substances Gastroenterology 2-Pyridinylmethylsulfinylbenzimidazoles Helicobacter Infections Pharmacotherapy Clarithromycin Internal medicine Gastroscopy medicine Humans Stomach Ulcer Helicobacter Dyspepsia Purpura Thrombocytopenic Idiopathic Helicobacter pylori biology Platelet Count business.industry Amoxicillin Hematology General Medicine Anti-Ulcer Agents biology.organism_classification medicine.disease Thrombocytopenic purpura digestive system diseases Anti-Bacterial Agents Gastritis Drug Therapy Combination medicine.symptom business medicine.drug
Zdroj:	Platelets. 18:52-55
ISSN:	1369-1635 0953-7104
DOI:	10.1080/09537100600864244
Popis:	Discrepant outcomes of Helicobacter pylori eradication in patients with idiopathic thrombocytopenic purpura have been reported. Here patients with dyspepsia and no other complications underwent gastroendoscopic examination and evaluation for Helicobacter pylori infection. Helicobacter pylori-infected patients with gastritis and gastric ulcer received eradication therapy: lansoprazole (60 mg/day), clarithromycin (400 mg/day), and amoxicillin (1500 mg/day) for 1 week. Lansoprazole 30 mg/day was administrated additional 7 weeks. Peripheral platelets were counted before treatment, 8 weeks after initiation of therapy, and at follow-up periods. Platelet counts in patients with both gastritis and gastric ulcer were evaluated with reference to the presence of Helicobacter pylori infection. Eighty-seven patients with gastritis and 35 of those with gastric ulcer underwent successful eradication therapy. Peripheral platelet counts in patients with gastritis decreased from 235+/-55 to 228+/-58 (10(3)/microL) (p=0.0337), and those with gastric ulcer decreased from 248+/-60 to 232+/-48 (10(3)/microL) (p=0.020) 8 weeks after initiation of therapy. Non-eradicated patients did not show such a tendency. Helicobacter pylori eradication reduced peripheral platelet counts in patients with gastritis and gastric ulcer. Amelioration of thrombocytopenia by eradicating Helicobacter pylori appears to involve mechanisms specific to idiopathic thrombocytopenic purpura.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::37581d9d3cdca6e63ca877cfb49b6150 https://doi.org/10.1080/09537100600864244 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
Nepřihlášeným uživatelům se plný text nezobrazuje	K zobrazení výsledku je třeba se přihlásit.