Cell cycle checkpoint regulators reach a zillion
| Autor: | Keith G. Kozminski, Kimberly M Yasutis |
|---|---|
| Rok vydání: | 2013 |
| Předmět: |
Cell cycle checkpoint
biology Cell growth Mitosis Cell Biology Polo-like kinase Cell Cycle Checkpoints Saccharomyces cerevisiae Review G2-M DNA damage checkpoint Cell cycle Cyclin-Dependent Kinases Cell biology Cyclin-dependent kinase biology.protein Animals Humans CHEK1 Protein Phosphatase 2 Molecular Biology Developmental Biology Adaptor Proteins Signal Transducing Signal Transduction |
| Zdroj: | Cell cycle (Georgetown, Tex.). 12(10) |
| ISSN: | 1551-4005 |
| Popis: | Entry into mitosis is regulated by a checkpoint at the boundary between the G2 and M phases of the cell cycle (G2/M). In many organisms, this checkpoint surveys DNA damage and cell size and is controlled by both the activation of mitotic cyclin-dependent kinases (Cdks) and the inhibition of an opposing phosphatase, protein phosphatase 2A (PP2A). Misregulation of mitotic entry can often lead to oncogenesis or cell death. Recent research has focused on discovering the signaling pathways that feed into the core checkpoint control mechanisms dependent on Cdk and PP2A. Herein, we review the conserved mechanisms of the G2/M transition, including recently discovered upstream signaling pathways that link cell growth and DNA replication to cell cycle progression. Critical consideration of the human, frog and yeast models of mitotic entry frame unresolved and emerging questions in this field, providing a prediction of signaling molecules and pathways yet to be discovered. |
| Databáze: | OpenAIRE |
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