The dynamic genome of Hydra

Autor: Philip A. Wigge, Lakshmi D. Viswanathan, Bert Hobmayer, J. Craig Venter, Catherine E. Dana, Daniel E. Martínez, Georg Hemmrich, Toshitaka Fujisawa, Simon E. Prochnik, Thomas C. G. Bosch, Anne Kathrin Gorny, Andre Franke, Willi Salvenmoser, René Augustin, Ewen F. Kirkness, Charles N. David, Xiaoming Zhang, Bianca Bertulat, Prakash G. Balasubramanian, Angelika Böttger, Chiemi Nishimiya-Fujisawa, Shiho Hayakawa, Patrick Tischler, Lydia Gee, Thomas Weinmaier, Jung Shan Hwang, Hans R. Bode, Kazuho Ikeo, Toshio Takahashi, Brian P. Walenz, Hiroshi Watanabe, Takashi Gojobori, Karin A. Remington, Yukio Nakamura, Kevin J. Peterson, Roland Aufschnaiter, Corina Guder, Benjamin M. Wheeler, Thomas Rattei, Alexander Wolf, Uffe Hellsten, Jisong Peng, Robert Steele, Jarrod Chapman, Daniel S. Rokhsar, Eisuke Hayakawa, Steven E. Hampson, Therese Mitros, Jon Borman, Sebastian Fraune, Ulrich Technau, Shengquiang Shu, Granger G. Sutton, Dana A. Busam, Patrick R. H. Steinmetz, Nadezhda Sumin, Konstantin Khalturin, Mamiko Hirose, Kathryn Disbennett, Atshushi Ogura, Marie Kristin Eder, Cynthia Pfannkoch, Dennis F. Kibler, Robert L. Strausberg, Alysha M. Heimberg, Bruce Blumberg, Lee Law, Oleg Simakov, Nicholas H. Putnam, Thomas W. Holstein, Suat Özbek, Dirk Lindgens, Takeshi Kawashima, David Goodstein
Rok vydání: 2010
Předmět:
Zdroj: Nature. 464:592-596
ISSN: 1476-4687
0028-0836
DOI: 10.1038/nature08830
Popis: The freshwater cnidarian Hydra was first described in 17021 and has been the object of study for 300 years. Experimental studies of Hydra between 1736 and 1744 culminated in the discovery of asexual reproduction of an animal by budding, the first description of regeneration in an animal, and successful transplantation of tissue between animals2. Today, Hydra is an important model for studies of axial patterning3, stem cell biology4 and regeneration5. Here we report the genome of Hydra magnipapillata and compare it to the genomes of the anthozoan Nematostella vectensis6 and other animals. The Hydra genome has been shaped by bursts of transposable element expansion, horizontal gene transfer, trans-splicing, and simplification of gene structure and gene content that parallel simplification of the Hydra life cycle. We also report the sequence of the genome of a novel bacterium stably associated with H. magnipapillata. Comparisons of the Hydra genome to the genomes of other animals shed light on the evolution of epithelia, contractile tissues, developmentally regulated transcription factors, the Spemann–Mangold organizer, pluripotency genes and the neuromuscular junction.
Databáze: OpenAIRE
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