Posterior pelvic exenteration for primary rectal cancer

Autor: J. E. Mansilla, Carlos Melo, Guillermo Bannura, Daniel Soto, Alejandro Barrera, Miguel Angel Cumsille, Jaime Contreras
Rok vydání: 2006
Předmět:
Zdroj: Colorectal Disease. 8:309-313
ISSN: 1463-1318
1462-8910
Popis: Background Indications for and the prognosis of posterior pelvic exenteration (PPE) in rectal cancer patients are not clearly defined. The aim of this study was to analyse the indications, complications and long-term results of PPE in patients with primary rectal cancer. Methods A retrospective review included patient demographics, tumour and treatment variables, and morbidity, recurrence, and survival statistics. These results were compared with a group of female patients who underwent standard resection for primary rectal cancer in the same period (non PPE group). Results The series included 30 women with an average age of 56.7 years (range 22–78). Tumour location was recorded in three cases in the upper rectum, 13 cases in the medium rectum and 14 cases in the lower rectum. A sphincter-preserving procedure was performed in 70% of the patients. Mean operative time was 4.2 h (range 2–7.5 h). Overall major morbidity rate in this series was 50% and mean hospital stay was 19.7 days (range 9–60 days). There was no hospital mortality. Pathological reports showed direct invasion of uterus, vagina or rectovaginal septum in 19 cases, involvement of perirectal tissue in 25 cases and positive lymph nodes in 18 cases. Comparison between PPE and non PPE groups showed no differences in mean tumour diameter, histological grade and tumour stage, but patients in the first group were younger. Although low tumours were seen more frequently in the PPE group (P = 0.003), the rate of sphincter-preserving procedure was comparable in both groups. Operative time was longer (P = 0.04) and morbidity was higher (P = 0.0058) in the PPE group. Local recurrence with or without distant metastases for the whole series was 30%. Five-year survival rate for patients who underwent curative resections (TNM I–III) was 48% in the PPE group vs 62% in the non PPE group (P = 0.09). Conclusions In the present series, PPE prolonged operative time, increased postoperative complications and showed a trend toward poor prognosis in recurrence and survival. However, PPE offers the only hope for cure to patients with a primary rectal cancer that is adherent or invades reproductive organs.
Databáze: OpenAIRE
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