| Autor: |
Paul J. F. Rider, Mohd Kamil, Ilknur Yilmaz, Habibe N. Atmaca, Merve Kalkan-Yazici, Mehmet Ziya Doymaz, Konstantin G. Kousoulas, Ahmed S. I. Aly |
| Přispěvatelé: |
ALY, Ahmed Sayed Ibrahım, KAMIL, MOHD, YAZICI, MERVE |
| Rok vydání: |
2022 |
| Předmět: |
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| Popis: |
Here, we present the construction of an attenuated herpes simplex virus type-1 (HSV-1)-vectored vaccine, expressing three liver-stage (LS) malaria parasite exported proteins (EXP1, UIS3 and TMP21) as fusion proteins with the VP26 viral capsid protein. Intramuscular and subcutaneous immunizations of mice with a pooled vaccine, composed of the three attenuated virus strains expressing each LS antigen, induced sterile protection against the intravenous challenge of Plasmodium yoelii 17X-NL salivary gland sporozoites. Our data suggest that this malaria vaccine may be effective in preventing malaria parasite infection using practical routes of immunization in humans. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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