Erythema multiform-like lesions in a patient infected with SARS-CoV-2: a case report
| Autor: | Reza Mottaghi, Yaser Fathi, Elaheh Ghasemzadeh Hoseini |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Target lesion
medicine.medical_specialty hydroxychloroquine Erythema ribavirin target lesion Mucocutaneous zone Case Report hypersensitivity reaction 030207 dermatology & venereal diseases 03 medical and health sciences 0302 clinical medicine Virology oral ulceration medicine erythema multiform Erythema multiforme skin and connective tissue diseases Respiratory distress integumentary system mucocutaneous lesion business.industry COVID-19 Hydroxychloroquine 030206 dentistry medicine.disease Dermatology Hypersensitivity reaction atypical target Differential diagnosis medicine.symptom business lip crusting medicine.drug |
| Zdroj: | Future Virology |
| ISSN: | 1746-0808 1746-0794 |
| Popis: | Background: SARS-CoV-2, is followed by several manifestations, such as fever, cough, respiratory distress syndrome and mucocutaneous lesions such as papules, urticaria, vasculitic purpura and erythema multiform. Case: A 22-year old woman was diagnosed with COVID-19. Considering the skin and oral lesions, erythema multiform was suggested as the most likely diagnosis. Oral valaciclovir was administered. Discussion: Erythema multiforme were reported in some patients with COVID-19. Its pathophysiology is not yet completely understood, but it seems there is a lymphocyte-mediated hypersensitivity reaction to SARS-CoV-2 antigens presenting in the skin. Conclusion: Mucocutaneous and oral lesions might be the first manifestations of COVID-19. Therefore, during the pandemic, it is prudent to consider this virus as a differential diagnosis once we encounter oral ulceration. Lay abstract We reported a 22-year old woman admitted to the hospital complaining of fever, abdominal pain, nausea and occasional vomiting that started about a week prior. According to the CT scan and real-time reverse transcription polymerase chain reaction (rRT-PCR), the patient was diagnosed with COVID-19. Oral examination by an oral medicine specialist revealed extensive ulcers in the mouth and crusts on the lips and she was diagnosed with erythema multiform. Oral valaciclovir was prescribed for 5 days and oral lesions relatively disappeared after 6 days. The pathophysiology of lesions is not yet completely understood, but it seems there is a hypersensitivity reaction to SARS-CoV-2 antigens presenting in the skin. SARS-CoV-2 could travel to other tissues such as skin, and make alterations to the cutaneous immune system, resulting in various manifestations on the skin. |
| Databáze: | OpenAIRE |
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