Fluctuations in vancomycin CNS tissue concentrations following intermittent and continuous infusions in the rat
| Autor: | Melissa Shannon, Mark S. Luer, Aaron D. Killian, Keith A. Rodvold, Bill J. Gurley, Kathryn K. Neill |
|---|---|
| Rok vydání: | 2004 |
| Předmět: |
Central Nervous System
Male Microdialysis Pharmacology CNS tissue Drug Administration Schedule Rats Sprague-Dawley Intermittent dosing Vancomycin Extracellular fluid Animals Medicine Tissue Distribution Dosing interval Infusions Intravenous business.industry General Medicine Intravenous Infusions Serum concentration Anti-Bacterial Agents Rats Neurology Anesthesia sense organs Neurology (clinical) Drug Monitoring business Chromatography Liquid medicine.drug |
| Zdroj: | Neurological Research. 26:312-315 |
| ISSN: | 1743-1328 0161-6412 |
| DOI: | 10.1179/016164104225014012 |
| Popis: | The purpose of this investigation was to compare the variability of vancomycin concentrations in the serum and CNS when administered continuously or as intermittent intravenous infusions in the rat. The hypothesis for this investigation was that the magnitude of change in serum vancomycin concentrations directly relates to the extent of vancomycin concentration fluctuations in the CNS. Microdialysis and serum sampling techniques were employed and biologic samples were analysed for vancomycin using HPLC. Over the dosing interval, the mean changes in concentrations were 71.8 +/- 9.8% and 13.6 +/- 9.3% for serum and 61.7 +/- 7.8% and 6.8 +/- 3.5% for brain extracellular fluid in the intermittent and continuously infused groups, respectively. Accordingly, the relative changes in vancomycin concentrations in brain extracellular fluid were closely associated with corresponding changes in serum concentrations (R2=0.94). Thus, continuous intravenous administration of vancomycin results in minimal serum and CNS tissue concentration changes as compared to traditional intermittent dosing methods and allows for more consistent vancomycin concentrations in the CNS. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|