Impaired platelet nitric oxide response in patients with new onset atrial fibrillation
Autor: | Doan T.M. Ngo, Jocasta Ball, Elaine M. Hylek, Saifei Liu, Melinda Carrington, Vincent Goh, Tamila Heresztyn, Vivek B. Nooney, Irene Stafford, John D. Horowitz, Nathan E.K. Procter, Nicola L. Hurst, Simon Stewart, Yuliy Y. Chirkov, Jeffrey S. Isenberg |
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Přispěvatelé: | Procter, Nathan EK, Ball, Jocasta, Liu, Saifei, Hurst, Nicola L, Nooney, Vivek B, Goh, Vincent, Stafford, Irene, Heresztyn, Tamila, Carrington, Melinda, Ngo, Doan TM, Hylek, Elaine M, Isenberg, Jeffrey S S, Chirkov, Yuliy Y, Stewart, Simon, Horowitz, John D |
Rok vydání: | 2015 |
Předmět: |
Blood Platelets
Male medicine.medical_specialty Platelet Function Tests Nitric Oxide Nitric oxide chemistry.chemical_compound nitric oxide Risk Factors Internal medicine Atrial Fibrillation medicine Humans atrial fibrillation Platelet Aged Whole blood Aged 80 and over Ejection fraction biology business.industry Atrial fibrillation Angiotensin-converting enzyme Middle Aged medicine.disease chemistry platelets biology.protein Cardiology Female Sodium nitroprusside Cardiology and Cardiovascular Medicine business Asymmetric dimethylarginine medicine.drug |
Zdroj: | International Journal of Cardiology. 179:160-165 |
ISSN: | 0167-5273 |
Popis: | Background: Clinical factors associated with thromboembolic risk in AF patients are well characterized and include new onset AF. Biochemically, AF is associated with inflammatory activation and impairment of nitric oxide (NO) signalling, which may also predispose to thromboembolism: the bases for variability in these anomalies have not been identified. We therefore sought to identify correlates of impaired platelet NO signalling in patients hospitalized with atrial fibrillation (AF), and to evaluate the impact of acuity of AF. Methods: 87 patients hospitalized with AF were evaluated. Platelet aggregation, and its inhibition by the NO donor sodium nitroprusside, was evaluated using whole blood impedance aggregometry. Correlates of impaired NO response were examined and repeated in a “validation” cohort of acute cardiac illnesses. Results Whilst clinical risk scores were not significantly correlated with integrity of NO signalling, new onset AF was associated with impaired NO response (6 ± 5% inhibition versus 25 ± 4% inhibition for chronic AF, p < 0.01). New onset AF was a multivariate correlate (p < 0.01) of impaired NO signalling, along with platelet ADP response (p < 0.001), whereas the associated tachycardia was not. Platelet ADP response was predicted by elevation of plasma thrombospondin-1 concentrations (p < 0.01). Validation cohort evaluations confirmed that acute AF was associated with significant (p < 0.05) impairment of platelet NO response, and that neither acute heart failure nor acute coronary syndromes were associated with similar impairment. Conclusion Recent onset of AF is associated with marked impairment of platelet NO response. These findings may contribute to thromboembolic risk in such patients. Refereed/Peer-reviewed |
Databáze: | OpenAIRE |
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