Transcranial Direct Current Stimulation over the Dorsolateral Prefrontal Cortex in Schizophrenia: A Quantitative Review of Cognitive Outcomes
| Autor: | Elias Boroda, Riley Capizzi, Angus W. MacDonald, Joshua E. Mervis |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
cognition
Psychosis Mini Review medicine.medical_treatment Stimulation quantitative review 03 medical and health sciences Behavioral Neuroscience 0302 clinical medicine medicine Biological Psychiatry dorsolateral prefrontal cortex Transcranial direct-current stimulation Working memory Cognition Neurophysiology medicine.disease 030227 psychiatry Dorsolateral prefrontal cortex Psychiatry and Mental health Neuropsychology and Physiological Psychology medicine.anatomical_structure Neurology Schizophrenia transcranial direct current stimulation Psychology Neuroscience 030217 neurology & neurosurgery Cognitive psychology |
| Zdroj: | Frontiers in Human Neuroscience |
| ISSN: | 1662-5161 |
| DOI: | 10.3389/fnhum.2017.00044 |
| Popis: | Cognitive deficits are a core and disabling feature of psychotic disorders, specifically schizophrenia. Current treatments for impaired cognition in schizophrenia remain insufficient. Recent research suggests transcranial direct current stimulation (tDCS) targeting the dorsolateral prefrontal cortex can potentiate cognitive improvements in healthy individuals and those with psychiatric conditions, such as schizophrenia. However, this burgeoning literature has not been quantitatively evaluated. Through a literature search and quantitative review, we identified 194 papers on tDCS, psychosis, and cognition. Selection criteria included pre/post design and sham control to achieve specific sham-adjusted effect sizes. The 6 retained studies all address schizophrenia populations and include single and repeated stimulation, as well as within and between subject designs. Small positive effects were found for anodal stimulation on behavioral measures of attention and working memory, with tentative findings for cognitive ability and memory. Cathodal stimulation yielded a small positive effect on behaviorally measured cognitive ability. Neurophysiological measures of attention showed a small to medium down-modulation effect for anodal stimulation. Implications of these findings and guidelines for future research are discussed. As revealed by this report, due to the paucity of data available, much remains unknown regarding the clinical efficacy of tDCS in schizophrenia. |
| Databáze: | OpenAIRE |
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