Relationship between episodic memory and volume of the brain regions of two functional cortical memory systems in multiple sclerosis
| Autor: | Juan Antonio Hernández-Tamames, Laudino López-Alvarez, Jorge Mario Sánchez-Reyes, Helena Melero, Marta Cerezo-García, Israel Thuissard, Sandra Rubio-Fernández, Yolanda Aladro |
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| Přispěvatelé: | Radiology & Nuclear Medicine |
| Rok vydání: | 2018 |
| Předmět: |
Adult
Male 0301 basic medicine Minusvalías Wechsler Memory Scale Memory Episodic Precuneus Hippocampus Multiminusválido Grey matter White matter 03 medical and health sciences Multiple Sclerosis Relapsing-Remitting 0302 clinical medicine Visual memory Memorización Parietal Lobe medicine Memoria Humans Cognitive Dysfunction Gray Matter Episodic memory Cerebral Cortex business.industry Middle Aged Magnetic Resonance Imaging 030104 developmental biology medicine.anatomical_structure Neurology Esclerosis múltiple Posterior cingulate Female Neurology (clinical) Atrophy Nerve Net business Enfermedad Neuroscience 030217 neurology & neurosurgery |
| Zdroj: | Journal of Neurology, 265(10), 2182-2189. D. Steinkopff-Verlag |
| ISSN: | 1432-1459 0340-5354 |
| Popis: | Background/objective: Two functional networks are proposed as neuronal support for the complex processes of memory: the anterior temporal and the medial posterior systems. We examined the atrophy of hippocampus (HC) and of those areas constituting the two functional memory systems in multiple sclerosis (MS) patients with low disability. Methods: Episodic memory (EM) was assessed in 88 relapsing MS patients and in 40 healthy controls using Wechsler Memory Scale III (Spanish adaptation). FreeSurfer software was used to calculate normalized volume of total cortex, grey matter, white matter, subcortical grey matter (thalamus and striatum), HC and both the anterior temporal (entorhinal, ventral temporopolar, lateral orbitofrontal, amygdala) and posterior medial systems (thalamus, parahippocampal, posterior cingulate, precuneus, lateral parietal and medial prefrontal). Linear regression analysis was used to identify predictors of memory performance. Results: Total grey matter and cortex volumes correlated with all subtypes of EM, and the precuneus volume correlated with overall, immediate and delayed memories. Univariant regression analysis identified an association between the volumes of the posterior medial memory network regions and EM scores. The volume of the left precuneus area was the unique and independent predictor for all EM subtypes except for visual memory, for which left HC volume was also an independent predictor. Conclusion: Left precuneus volume was the best predictor of memory in relapsing MS patients with low disability and mild deficits in EM. Sin financiación 4.204 JCR (2018) Q1, 41/199 Clinical Neurology 1.432 SJR (2018) Q1, 66/378 Neurology (clinical) No data IDR 2018 UEM |
| Databáze: | OpenAIRE |
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