Optimization of reconstruction and quantification of motion-corrected coronary PET-CT

Autor: Sandeep K. Krishnan, Adam M. Alessio, Yuka Otaki, Sebastien Cadet, Mhairi K. Doris, Jacek Kwiecinski, Damini Dey, David E. Newby, Mathieu Rubeaux, Marc R. Dweck, Piotr J. Slomka, Daniel S. Berman, Tinsu Pan
Rok vydání: 2018
Předmět:
Male
Fluorine Radioisotopes
Image Processing
Signal-To-Noise Ratio
Cardiorespiratory Medicine and Haematology
030204 cardiovascular system & hematology
Cardiovascular
Coronary artery disease
030218 nuclear medicine & medical imaging
Electrocardiography
Computer-Assisted
0302 clinical medicine
Diastole
Positron Emission Tomography Computed Tomography
Medicine
Computed tomography
medicine.diagnostic_test
Noninvasive cardiac imaging
Heart
Middle Aged
Heart Disease
Positron emission tomography
Tracer uptake
Biomedical Imaging
Female
Cardiology and Cardiovascular Medicine
Acute coronary syndrome
Culprit
Motion
03 medical and health sciences
Text mining
Fluorodeoxyglucose F18
Cardiac motion
Clinical Research
Humans
Radiology
Nuclear Medicine and imaging
Aged
PET-CT
business.industry
Reproducibility of Results
Atherosclerosis
medicine.disease
Cardiovascular System & Hematology
Positron-Emission Tomography
Radiopharmaceuticals
business
Nuclear medicine
Pet quantification
Zdroj: Doris, M K, Otaki, Y, Krishnan, S K, Kwiecinski, J, Rubeaux, M, Alessio, A, Pan, T, Cadet, S, Dey, D, Dweck, M R, Newby, D E, Berman, D S & Slomka, P J 2018, ' Optimization of reconstruction and quantification of motion-corrected coronary PET-CT ', Journal of Nuclear Cardiology . https://doi.org/10.1007/s12350-018-1317-5
Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology, vol 27, iss 2
ISSN: 1532-6551
1071-3581
Popis: BACKGROUND: Coronary PET shows promise in the detection of high-risk atherosclerosis, but there remains a need to optimize imaging and reconstruction techniques. We investigated the impact of reconstruction parameters and cardiac motion-correction in 18F Sodium Fluoride (18F-NaF) PET.METHODS: Twenty-two patients underwent 18F-NaF PET within 22 days of an acute coronary syndrome. Optimal reconstruction parameters were determined in a subgroup of six patients. Motion-correction was performed on ECG-gated data of all patients with optimal reconstruction. Tracer uptake was quantified in culprit and reference lesions by computing signal-to-noise ratio (SNR) in diastolic, summed, and motion-corrected images.RESULTS: Reconstruction using 24 subsets, 4 iterations, point-spread-function modelling, time of flight, and 5-mm post-filtering provided the highest median SNR (31.5) compared to 4 iterations 0-mm (22.5), 8 iterations 0-mm (21.1), and 8 iterations 5-mm (25.6; all P CONCLUSIONS: The number of iterations and extent of post-filtering has marked effects on coronary 18F-NaF PET quantification. Cardiac motion-correction improves discrimination between culprit and reference lesions.
Databáze: OpenAIRE
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