Not lost in host translation: The new roles of long noncoding RNAs in infectious diseases
| Autor: | Caroline Reisacher, Laurence Arbibe |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Proteomics
Immunology Computational biology Biology Communicable Diseases Microbiology Ribosome Open Reading Frames 03 medical and health sciences Virology Animals Humans Ribosome profiling ORFS 030304 developmental biology Regulation of gene expression 0303 health sciences 030306 microbiology Gene Expression Profiling RNA Translation (biology) Gene expression profiling Protein Biosynthesis RNA Long Noncoding Peptides Ribosomes |
| Zdroj: | Cellular Microbiology. 21 |
| ISSN: | 1462-5822 1462-5814 |
| Popis: | Long non-coding RNAs (lncRNAs) play a central role in the regulation of gene expression. Although they were initially described as mRNA-like transcripts not encoding proteins, global approaches such as ribosome profiling have shown that they frequently associate with ribosomes, opening the possibility that lncRNAs are a source of cryptic translation events with functional roles. Recent studies have shed more light on small ORFs borne by lncRNAs and encoding short peptides potentially involved in infectious immunity. This review outlines the main strategies used to determine the coding potential of lncRNAs and discusses our emerging understanding of the implication of the encoded peptides in infectious diseases. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|