Healing characteristics of intraarterial stent grafts in an injured artery model
| Autor: | Mitchell H. Goldman, Mark P. Ombrellaro, David A. Weatherford, Dorcas O. Schaeffer, Michael B. Freeman, Scott L. Stevens, Jill E. Sackman Dr. |
|---|---|
| Rok vydání: | 1997 |
| Předmět: |
medicine.medical_specialty
Intimal hyperplasia Time Factors Infrarenal aorta medicine.medical_treatment Urology Catheterization Dogs Smooth muscle medicine Animals Aorta Abdominal Polytetrafluoroethylene Distal anastomosis Wound Healing Hyperplasia business.industry Stent General Medicine medicine.disease Balloon injury Surgery Blood Vessel Prosthesis medicine.anatomical_structure Stents Endothelium Vascular Cardiology and Cardiovascular Medicine business Tunica Intima Tunica Media Artery |
| Zdroj: | Annals of vascular surgery. 11(1) |
| ISSN: | 0890-5096 |
| Popis: | Previous investigations reveal in the absence of endothelial cell (EC) injury, intraarterial polytetrafluoroethylene (PTFE) stent graft (SG) exhibit greater EC repaving than PTFE interposition grafts (CG). The investigation evaluated EC repaving of SG compared to CG after balloon injury. Twenty adult dogs underwent SG (n = 10) or CG (n = 10) placement in the infrarenal aorta after balloon injury with harvest at 1 and 6 weeks. Endothelial repaving, intima-to-media height ratios (IMHR), and inflammatory stains were performed. Endothelial repaving was greater in 6-week SG compared to CG (51% +/- 5.0 versus 10% +/- 5.0, por = 0.05). IMHR was less in 6-week SG compared to CG at the proximal (1.22 +/- 0.16 versus 1.82 +/- 0.16, por = 0.05) and distal anastomosis (0.81 +/- 0.25 versus 1.33 +/- 0.25, por = 0.05). Smooth muscle cell (SMC) alpha-actin was greater in 1-week SG compared to CG at the distal anastomosis (121.5 +/- 7.2 versus 94.0 +/- 7.2, por = 0.05). Proliferating cell nuclear antigen (PCNA) was less in 6-week SG compared to CG at the proximal (5.6 +/- 1.4 versus 9.4 +/- 1.1, por = 0.05) and distal anastomosis (3.8 +/- 0.6 versus 11.2 +/- 1.1, por = 0.05). Macrophage CD-44 was less in 6-week SG compared to CG at the proximal (10.4 +/- 1.6 versus 32.6 +/- 3.6, por = 0.05) and distal anastomosis (8.6 +/- 0.9 versus 35.6 +/- 3.6, por = 0.05). Intraarterial SG placed after balloon injury exhibited significantly greater endothelialization and less intimal hyperplasia when compared to CG. |
| Databáze: | OpenAIRE |
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