Clinical relevance of lysyl oxidase-like 2 and functional mechanisms in glioma
| Autor: | Xiao-Guang Du, Mei-Jia Zhu |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Gene knockdown LOXL2 Immunoprecipitation Cell growth Chemistry Lysyl oxidase invasion medicine.disease OncoTargets and Therapy HDAC2 03 medical and health sciences 030104 developmental biology Oncology glioma Glioma medicine Cancer research Pharmacology (medical) prognosis Viability assay Original Research Proto-oncogene tyrosine-protein kinase Src |
| Zdroj: | OncoTargets and therapy |
| ISSN: | 1178-6930 |
| Popis: | Xiao-Guang Du,1,2 Mei-Jia Zhu1 1Department of Neurology, Qianfoshan Hospital Affiliated to Shandong University, Jinan, Shandong, People’s Republic of China; 2Department of Neurology, Weifang People’s Hospital, Weifang, Shandong, People’s Republic of China Introduction: Glioma is the most frequent malignancy of the adult central nervous system with high recurrence risk and poor prognosis. Understanding the biological molecular mechanisms involved in glioma progression is critical for studying oncogenic mechanisms and improving prognosis. Lysyl oxidase-like 2 (LOXL2) is a kind of lysyl oxidase catalyzing the formation of peptidyl-lysine residues and promoting intramolecular cross-linking, especially for proteins in extracellular matrix. Our study explored the expression pattern of LOXL2 in glioma for the first time and found that its high expression was associated with larger tumor size and advanced tumor grade (P |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|