Hyaluronic Acid Injection Laryngoplasty for Unilateral Vocal Fold Paralysis—A Systematic Review and Meta-Analysis
Autor: | Yu-Kang Tu, Wen-Jiun Lin, Shih-An Liu, Shang-Heng Wu, Chen-Chi Wang |
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Jazyk: | angličtina |
Rok vydání: | 2020 |
Předmět: |
MEDLINE
Review Vocal Cords Cochrane Library Injections 03 medical and health sciences chemistry.chemical_compound Laryngoplasty 0302 clinical medicine Swallowing Surveys and Questionnaires Hyaluronic acid hyaluronic acid Medicine Humans unilateral vocal fold paralysis Phonation 030223 otorhinolaryngology lcsh:QH301-705.5 injection laryngoplasty business.industry General Medicine Injection laryngoplasty meta-analysis chemistry lcsh:Biology (General) 030220 oncology & carcinogenesis Meta-analysis Anesthesia Inclusion and exclusion criteria business Vocal Cord Paralysis |
Zdroj: | Cells Cells, Vol 9, Iss 2417, p 2417 (2020) |
ISSN: | 2073-4409 |
Popis: | Unilateral vocal fold paralysis (UVFP) is a common disorder that may cause glottal closure insufficiency and then hoarseness of voice and aspiration during swallowing. We conducted a systematic review and meta-analysis to evaluate whether hyaluronic acid (HA) injection laryngoplasty (IL) is an effective treatment for patients with UVFP. Comprehensive systematic searches were undertaken using PubMed, EBSCO Medline, and Cochrane Library databases. We appraised the quality of studies according to preset inclusion and exclusion criteria. The lengths of follow-up were divided into “short-term” (3 months or shorter), “medium-term” (6 months), and “long-term” (12 months or longer). We performed random-effect meta-analysis to estimate the changes in voice-related quality of life, perceptual evaluation by grading systems, voice lab analysis of maximal phonation time, and normalized glottal gap area, before and after HA IL. Fourteen studies were eligible for the final analysis. The results showed that patients’ glottal closure insufficiency could be improved; maximal phonation time could be prolonged; perceptual evaluations of the voice and quality of life were better after HA IL, but the duration of treatment effect varied among different studies. In conclusion, HA IL is an effective treatment for UVFP, which may achieve a long-term effect and therefore reduce the likelihood of requiring permanent medialization thyroplasty. |
Databáze: | OpenAIRE |
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