Distribution and biochemical effects of pentylenetetrazol in brains of swine treated with a polychlorinated biphenyl
| Autor: | E.J. Van Loon, E.G. Mimnaugh, E. Miller, E. Peters, S. Edelman, Charles L. Litterst |
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| Rok vydání: | 1974 |
| Předmět: |
Male
Cerebellum medicine.medical_specialty Chromatography Gas Time Factors Swine Caudate nucleus Miniature swine Toxicology Aminobutyric acid Norepinephrine chemistry.chemical_compound Seizures Internal medicine medicine Animals Pentylenetetrazol Medulla Medulla Oblongata Chemistry organic chemicals Aminobutyrates Body Weight food and beverages Brain General Medicine Organ Size Dihydroxyphenylalanine Polychlorinated Biphenyls medicine.anatomical_structure Endocrinology Spectrometry Fluorescence Spinal Cord Organ Specificity Anesthesia Pentylenetetrazole Caudate Nucleus medicine.drug |
| Zdroj: | Chemico-biological interactions. 8(4) |
| ISSN: | 0009-2797 |
| Popis: | In order to detect an effect on the CNS following treatment with polychlorinated biphenyls (PCB), pentylenetetrazol (PTZ) was administered to two groups of miniature swine. One group was a control and the other had been treated for 30 days with Aroclor 1254 (PCB) at a dose of 25 μg/kg in ground laboratory chow. No statistical difference was seen between the amount of PTZ administered or the time required to convulse for either group of animals. The total amount of PTZ found in brains of PCB-treated swine was less than from brains of control swine. Less PTZ was found in medulla and cerebellum from PCB-treated animals. The amount of PTZ found in motor cortex and in caudate nucleus from brains of PCB-treated swine was equal to the amounts found in similar structures of control brains. A 2–3-fold increase in dihydroxyphenylalanine (DOPA) levels was detected in motor cortex and medulla from PCB-treated animals, although levels of norepinephrine (NE) and gamma- aminobutyric acid (GABA) were unchanged from controls. It is concluded that PCB treatment had no effect on altering convulsive threshold of PTZ in swine, although PCB treatment does decrease the amount of PTZ in swine brains. Non-specific alterations in brain amine levels were also seen in PCB-treated swine. |
| Databáze: | OpenAIRE |
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