| Popis: |
The gut microbiota is crucial for physiological functions in the gut, whereas dysbiosis causes many diseases, local intestinal disease e.g., inflammatory bowel disease (IBD) and systemic such as sepsis or multiple organ dysfunction syndrome (MODS). Thirty-eight-negative kinase-1 (TNK1) expression is upregulated in intestine in response to various stressors and has been linked to intestine barrier breach. Intestine specific targeting of TNK1 prevents development of severe colitis. Role of TNK1 on shaping the gut microbiota has not been addressed so far. Here we report that gut-specific TNK1-loss impacts microbiota composition in healthy and colitis mice. We show that microbiota normalization between Tnk1-knockout (Tnk1-KO) and wild type (WT) mice mitigated colitis severity in WT mice. Altogether, our study suggests that TNK1 deletion ameliorated colitis severity by modulating intestinal microbiota. TNK1 might be a target in the intestinal epithelium for a promising therapeutic approach by maintaining intestinal homeostasis. |
