Implication of European-derived adiposity loci in African Americans
| Autor: | B. I. Freedman, Pamela J. Hicks, J. Xu, Bong H. Roh, Lynne E. Wagenknecht, Donald W. Bowden, Carl D. Langefeld, Maria R. Wing, Nicholette D. Palmer, Maggie C.Y. Ng, Jessica M. Hester, Jiang Li, Jill M. Norris |
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| Rok vydání: | 2011 |
| Předmět: |
Male
Genotype Cell Adhesion Molecules Neuronal Endocrinology Diabetes and Metabolism Alpha-Ketoglutarate-Dependent Dioxygenase FTO Medicine (miscellaneous) Genome-wide association study Single-nucleotide polymorphism Biology GPI-Linked Proteins Polymorphism Single Nucleotide Article White People SH2B1 Polymorphism (computer science) Genetic variation Humans Genetic Predisposition to Disease Obesity Allele Adaptor Proteins Signal Transducing Adiposity Genetic association Genetics Nutrition and Dietetics Body Weight Genetic Variation Membrane Proteins Proteins Middle Aged Black or African American Diabetes Mellitus Type 2 Receptor Melanocortin Type 4 Female Body mass index Genome-Wide Association Study Transcription Factors |
| Zdroj: | International Journal of Obesity. 36:465-473 |
| ISSN: | 1476-5497 0307-0565 |
| Popis: | Recent genome-wide association studies (GWAS) have identified multiple novel loci associated with adiposity in European-derived study populations. Limited study of these loci has been reported in African Americans. Here we examined the effects of these previously identified adiposity loci in African Americans. A total of 46 representative single-nucleotide polymorphisms (SNPs) in 19 loci that were previously reported in GWAS in Europeans (including FTO and MC4R) were genotyped in 4992 subjects from six African-American cohorts. These SNPs were tested for association with body mass index (BMI) after adjustment for age, gender, disease status and population structure in each cohort. Meta-analysis was conducted to combine the results. Meta-analysis of 4992 subjects revealed seven SNPs near four loci, including NEGR1, TMEM18, SH2B1 /ATP2A1 and MC4R, showing significant association at 0.005 |
| Databáze: | OpenAIRE |
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