Chemical Compositions and Antimutagenic Effects of Ethanolic Extracts of Stachys Thirkei and Stachys Annua subsp. Annua Using the Ames Assay
| Autor: | Gorkem Dulger, Pinar Goc Rasgele |
|---|---|
| Přispěvatelé: | [Belirlenecek] |
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Pharmacology
Salmonella Stachys thirkei biology Traditional medicine Strain (chemistry) 010405 organic chemistry Chemistry biology.organism_classification medicine.disease_cause 01 natural sciences 0104 chemical sciences Ames test Stachys annua subsp 010404 medicinal & biomolecular chemistry Ames assay Drug Discovery Plant species Microsome medicine Stachys annua Lamiaceae annua antimutagenicity |
| Popis: | In this study, antimutagenic effects of ethanolic extracts of Stachys thirkei and Stachys annua subsp. annua belonging to Lamiaceae family that grow in Duzce of Turkey were investigated on Salmonella typhimurium TA98 and TA100 strains without metabolic activation using Salmonella/microsome test system. Three different concentrations (0.025, 0.05 and 0.1 mg/plate) of the ethanolic extracts of S. thirkei and S. annua subsp. were used as active materials in which the major components were 2-ethylhexanol (30.012%) and 2-beta-pinene (26.40%), respectively. The highest concentration (0.1 mg/plate) of S. thirkei had a moderate antimutagenic effect on the Salmonella typhimurium TA98 strain with a 26.79% inhibition rate. It was also established that the extract of S. thirkei at highest concentration (0.1 mg/plate) exhibited strong antimutagenic effect (with 44.03% maximum inhibition) on TA100 strain. Furthermore, it was found that 0.05 mg/plate ethanolic extract showed moderate antimutagenic activity with 25.55% inhibition rate. The highest concentration (0.1 mg/plate) of ethanolic extract of S. annua subsp. showed moderate antimutagenic activity on both Salmonella typhimurium TA98 and TA100 strains with inhibition rates of 20.39 and 22.13%, respectively. No antimutagenic activity on Salmonella typhimurium TA98 and TA100 strains was observed at the lowest doses of both plant species. As a result, it is concluded that S. thirkei and annua subsp. have antimutagenic activity and further studies may be recommended in terms of different parameters. Duzce University Scientific Research FundDuzce University [2019.11.01.908] This study was supported by Duzce University Scientific Research Fund (Project Number, 2019.11.01.908). WOS:000626351900002 2-s2.0-85102246884 |
| Databáze: | OpenAIRE |
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