Palladium Catalyzed Domino Sonogashira Coupling of 2-Chloro-3-(Chloromethyl)Quinolines with Terminal Acetylenes Followed by Dimerization
| Autor: | Zahra Gholami-Koupaei, Simin Kaffash, Zahra Yasaei, Morteza Shiri |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
palladium catalyzed reaction
quinolines Polymers and Plastics Sonogashira cross-coupling 010405 organic chemistry Dimer Organic Chemistry Sonogashira coupling chemistry.chemical_element 010402 general chemistry 01 natural sciences Medicinal chemistry Domino 0104 chemical sciences Catalysis chemistry.chemical_compound Cascade reaction Terminal (electronics) chemistry domino reaction Materials Chemistry Palladium |
| Popis: | A domino Sonogashira coupling of 2-chloro-3-(chloromethyl)quinolines and terminal acetylenes and then dimerization is described. This palladium-catalyzed reaction gave novel dimer quinolinium salts in good to high yield. Based on empirical evidence, a plausible mechanism was provided. The produced quinolinium salt are amenable to further synthetic elaborations such as reactions with phenoxide and thiophenoxide to yield the corresponding ether and thioether. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|