Uropathogens antibiotic susceptibility as an indicator for the empirical therapy used for urinary tract infections: a retrospective observational study
| Autor: | Hala Haitham Abduljabbar, Adil Ghalib Fadil, Sarmad Abdul Abbas Kashmar, Jasim Mohammed Najm, Raad Saad Luty |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Microbiology (medical)
Imipenem Urinary tract infections lcsh:QR1-502 Tigecycline 01 natural sciences Microbiology lcsh:Microbiology chemistry.chemical_compound 0502 economics and business medicine polycyclic compounds Escherichia coli 0101 mathematics Antibiotics resistance Teicoplanin business.industry Sulfamethoxazole 010102 general mathematics 05 social sciences biochemical phenomena metabolism and nutrition bacterial infections and mycoses Ciprofloxacin Klebsiella pneumoniae chemistry Nitrofurantoin Linezolid Original Article business 050203 business & management medicine.drug Piperacillin |
| Zdroj: | Iranian Journal of Microbiology Iranian Journal of Microbiology, Vol 12, Iss 5 (2020) |
| ISSN: | 2008-4447 2008-3289 |
| Popis: | Background and Objectives: Urinary tract infection (UTI) is a common infection affects people of different ages. It is important to explore the antibiotics susceptibility of the bacterial agents to improve the empirical antibacterial prescription because of emerging of multi-drug resistant (MDR) bacteria. Materials and Methods: This is a retrospective observational study including 322 patients with UTI at the largest hospital at the center of Al-Basrah Governorate in the far south of Iraq from August 2018 to November 2019. Bacterial isolates from urine samples with significant bacteria were investigated by automated VITEK® 2 compact system to determine the causative bacteria and their antibiotics susceptibility. Results: Escherichia coli and Klebsiella pneumoniae were the first and second most frequent Gram-negative isolates, whereas Staphylococcus haemolyticus and Enterococcus faecalis were the first and second most frequent Gram-positive isolates. Fosfomycin, tigecycline, colistin, meropenem, imipenem, amikacin and nitrofurantoin had high susceptibility rates against Gram-negative isolates. Nitrofurantoin, tigecycline, daptomycin, teicoplanin, vancomycin and linezolid had a high effect against Gram-positive isolates. Conclusion: The leading causative isolates especially the most predominant Gram-negative isolates E. coli and K. pneumoniae show high resistance rates against important antibiotics including penicillin/β-lactamase inhibitors piperacillin/tazobactam, third-generation cephalosporins as ceftazidime, and cefepime quinolones as ciprofloxacin and levofloxacin and trimethoprim/sulfamethoxazole which call for reconsidering them for treatment of UTI. |
| Databáze: | OpenAIRE |
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