Hepatic regenerative response in small-sized liver isografts in the rat
| Autor: | Li Yong Pu, Ji Wei Zhong, Yan Yang, Xue Hao Wang, Lian Bao Kong, Yue Yu, Xian Zhong Liu, Xiangcheng Li, Feng Zhang, Ai Hua Yao |
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| Rok vydání: | 2008 |
| Předmět: |
MAPK/ERK pathway
Male STAT3 Transcription Factor medicine.medical_specialty Portal venous pressure medicine.medical_treatment Liver transplantation Cyclin D1 Internal medicine Proliferating Cell Nuclear Antigen Hypertension Portal medicine Animals Interleukin 6 STAT3 Mitogen-Activated Protein Kinase Kinases biology Interleukin-6 Portal Vein Cell Cycle Hemodynamics Cell cycle Portal Pressure Proliferating cell nuclear antigen Liver Regeneration Liver Transplantation Rats surgical procedures operative Endocrinology Liver Rats Inbred Lew Reperfusion Injury Immunology biology.protein Surgery Cell Division |
| Zdroj: | The Journal of surgical research. 161(2) |
| ISSN: | 1095-8673 |
| Popis: | Background To investigate hepatic regenerative response and associated mechanisms in different-size liver grafts in the rat. Methods Rat models of different-size-graft liver transplantation (whole, 50%-size, or 30%-size) were established, with a sham operation group serving as a control. Portal pressure, graft injury, interleukin 6 (IL-6), signal transducer and activator of transcription (Stat3), mitogen-activated protein kinase (MAPK), cyclin D1, and proliferating cell nuclear antigen (PCNA) were all assessed. Results The portal pressure was significantly higher and hepatic injury more severe in the smaller sized groups than in the whole graft group, especially in the 30%-size grafts. Hepatic IL-6 and tumor necrosis factor-α (TNF-α) levels in the two smaller sized groups were significantly higher than in the whole graft group, while IL-6 levels appeared to be negatively associated with graft sizes. Downstream markers of IL-6, Stat3 and MAPK phosphorylation, cyclin D1, and PCNA expression were also markedly increased in the small-sized grafts compared with the whole grafts, and appeared to positively correlate with early measurements of portal pressure and subsequent hepatic injury. Conclusion Vigorous hepatic regeneration in small-for-size liver grafts may be associated with highly activated IL-6/Stat3 and MAPK signaling, which may in turn correlate with graft size, portal pressure, and hepatic injury. |
| Databáze: | OpenAIRE |
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