Expression of Endothelin Receptors in Human Myometrium During Pregnancy and in Uterine Leiomyomas
| Autor: | Francçoise Ferré, Jean-claude Honoré, Michelle Breuiller-Fouché, Charles Chapron, Brigitte Robert, Marie-Cécile Vacher-Lavenu |
|---|---|
| Rok vydání: | 2000 |
| Předmět: |
medicine.medical_specialty
Indoles Uterus Biology Piperidines Downregulation and upregulation Pregnancy Internal medicine medicine Humans RNA Messenger Receptor Pharmacology Uterine leiomyoma Endothelin-1 Leiomyoma Phospholipase C Receptors Endothelin Myometrium Azepines Receptor Endothelin A musculoskeletal system Receptor Endothelin B female genital diseases and pregnancy complications medicine.anatomical_structure Endocrinology In utero Uterine Neoplasms Female Endothelin receptor Cardiology and Cardiovascular Medicine Oligopeptides |
| Zdroj: | Journal of Cardiovascular Pharmacology. 36:S386-S389 |
| ISSN: | 0160-2446 |
| DOI: | 10.1097/00005344-200036001-00112 |
| Popis: | The distribution of mRNAs for endothelinA and B (ET(A) and ET(B)) receptors and their binding properties was studied in human nonpregnant and pregnant term myometrium and in uterine leiomyomas. ET(A)- and ET(B)-receptors functionally coupled to phospholipase C (PLC) coexisted in myometrial tissues, but only the functional ET(A)-receptor subtype was detected in leiomyomas. ET(A)-receptor mRNA and three other spliced variants were distributed in all tissue studied. We reported an increase in the proportion of ET(A)-receptors coupled to PLC in term pregnant myometrium when compared to nonpregnant tissue. These results suggest that upregulation of the myometrial ET(A)-receptors may account for or contribute to the control of normal development and growth of human myometrium during pregnancy. They also support a pathological role for the endothelin-1 (ET-1)/ET(A)-receptor system in leiomyoma development. |
| Databáze: | OpenAIRE |
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