Deciphering the Message in Protein Sequences: Tolerance to Amino Acid Substitutions
| Autor: | John F. Reidhaar-Olson, Robert T. Sauer, Wendell A. Lim, James U. Bowie |
|---|---|
| Rok vydání: | 1990 |
| Předmět: |
Models
Molecular Protein Conformation Surface Properties Molecular Sequence Data Repressor Computational biology Biology DNA-binding protein Structure-Activity Relationship Viral Proteins Protein structure Computer Graphics Code (cryptography) Structure–activity relationship Viral Regulatory and Accessory Proteins Amino Acid Sequence Peptide sequence chemistry.chemical_classification Multidisciplinary fungi Proteins food and beverages Amino acid DNA-Binding Proteins Repressor Proteins Biochemistry chemistry Function (biology) |
| Zdroj: | Science. 247:1306-1310 |
| ISSN: | 1095-9203 0036-8075 |
| DOI: | 10.1126/science.2315699 |
| Popis: | An amino acid sequence encodes a message that determines the shape and function of a protein. This message is highly degenerate in that many different sequences can code for proteins with essentially the same structure and activity. Comparison of different sequences with similar messages can reveal key features of the code and improve understanding of how a protein folds and how it performs its function. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|