Leukotrienes C4 and D4 promote angiogenesis via a receptor-mediated interaction
| Autor: | Eva Pipili-Synetos, Nicos E. Tsopanoglou, Michael E. Maragoudakis |
|---|---|
| Rok vydání: | 1994 |
| Předmět: |
Receptors
Leukotriene Pharmacology Leukotriene Leukotriene D4 Dose-Response Relationship Drug Neovascularization Pathologic Leukotriene C4 Leukotriene B4 Leukotriene receptor Angiogenesis Extraembryonic Membranes Chick Embryo Cell biology Neovascularization chemistry.chemical_compound Chorioallantoic membrane Biochemistry chemistry medicine Animals Dicarboxylic Acids SRS-A medicine.symptom |
| Zdroj: | European Journal of Pharmacology. 258:151-154 |
| ISSN: | 0014-2999 |
| Popis: | The involvement of leukotrienes in angiogenesis was investigated in the in vivo chick chorioallantoic membrane system. In this system leukotrienes C4 and D4 promoted angiogenesis in a dose-dependent manner. Leukotriene B4 was ineffective. The potent and selective peptidyl leukotriene receptor antagonist, SK&F 104353-Z2, abolished the angiogenic effects of leukotrienes C4 and D4 and reduced unstimulated angiogenesis. These results indicate that leukotrienes C4 and D4 promote angiogenesis in the chick chorioallantoic membrane via a receptor-mediated interaction. |
| Databáze: | OpenAIRE |
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