The paradox of the role of resistin in early-onset obesity hypertension: A comparative study among four Chinese adult subgroups
| Autor: | Hu Zhang, Ou Wu, Jia Jia Li, Jian Hang Leng, Xingyu Zhang, Xi Lu, Fen Fang Yang |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Adult
Male China medicine.medical_specialty Physiology Serum albumin Blood Pressure 030204 cardiovascular system & hematology Body Mass Index 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine High-density lipoprotein Asian People Internal medicine Internal Medicine medicine Humans Resistin Obesity 030212 general & internal medicine Creatinine biology Triglyceride business.industry Albumin General Medicine Middle Aged Fructosamine Endocrinology Blood pressure chemistry Hypertension biology.protein Female Waist Circumference business Biomarkers |
| Zdroj: | Clinical and Experimental Hypertension. :1-7 |
| ISSN: | 1525-6006 1064-1963 |
| DOI: | 10.1080/10641963.2021.1883049 |
| Popis: | Objective: To explore the role of resistin in the onset and development of obesity-related hypertension.Methods: Resistin serum levels were tested by ELISA in 153 adult subjects among four characteristic Chinese adult physical examination groups. Waist circumference (WC), body mass index (BMI), systolic blood pressure (SB), diastolic blood pressure (DB), and other clinical laboratory data were collected. Following, correlations between research index and differences between groups were analyzed using SPSS.Results: Serum resistin levels statistically significantly negatively correlated with SB, DB and BMI, but statistically significantly positively correlated with serum creatinine (SCR) and serum albumin (ALB), even after adjustment for age and/or gender. The serum level of resistin in the normal healthy subject group (NH) was higher than in other groups.Conclusions: Resistin's role in the onset of obesity-related hypertension may be more important than what has been previously assumed. More pathway substances in the early onset of obesity-related hypertension should be tested.Abbreviations: WC, waist circumference; GGT, Gamma-glutamyltransferase; ALB, Albumin; ALT, Alanine aminotransferase; LDL, Low density lipoprotein cholesterol; TG, Triglyceride; HDLC, High density lipoprotein cholesterol; FA Fructosamine; SCR, serum creatinine; IB, Indirect bilirubin; ALP, Alkaline phosphatase; CB, Conjugated bilirubin; UREA, Urea; Ua, Uric acid; FBG, fasting blood glucose; TC, Total cholesterol; TB, Total bilirubin; TP, Total protein; TC/HDLC, TC/HDLC ratio; SB, systolic blood pressure; DB, diastolic blood pressure. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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