Functional connectivity for face processing in individuals with body dysmorphic disorder and anorexia nervosa
| Autor: | Susan Y. Bookheimer, Cara Bohon, Michael Strober, Jamie D. Feusner, Courtney Sheen, M. A. Sasaki, Teena D. Moody |
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| Rok vydání: | 2015 |
| Předmět: |
Adult
Male medicine.medical_specialty Anorexia Nervosa Adolescent media_common.quotation_subject Eating Disorders Audiology Article Developmental psychology Visual processing Young Adult Clinical Research Perception mental disorders medicine Psychology Humans Eye Disease and Disorders of Vision Applied Psychology media_common body dysmorphic disorder Psychiatry Cerebral Cortex Perceptual Distortion medicine.diagnostic_test psychophysiological interaction functional connectivity Psychophysiological Interaction Neurosciences Fusiform face area medicine.disease Serious Mental Illness Body Dysmorphic Disorders Magnetic Resonance Imaging Brain Disorders Anorexia Psychiatry and Mental health Mental Health Anorexia nervosa (differential diagnoses) Case-Control Studies Body dysmorphic disorder Public Health and Health Services Female Functional magnetic resonance imaging Insula Mind and Body Facial Recognition |
| Zdroj: | Psychological Medicine, vol 45, iss 16 Moody, TD; Sasaki, MA; Bohon, C; Strober, MA; Bookheimer, SY; Sheen, CL; et al.(2015). Functional connectivity for face processing in individuals with body dysmorphic disorder and anorexia nervosa. Psychological Medicine. doi: 10.1017/S0033291715001397. UCLA: Retrieved from: http://www.escholarship.org/uc/item/8b47b5xs Moody, TD; Sasaki, MA; Bohon, C; Strober, MA; Bookheimer, SY; Sheen, CL; et al.(2015). Functional connectivity for face processing in individuals with body dysmorphic disorder and anorexia nervosa. Psychological Medicine, 45(16), 3491-3503. doi: 10.1017/S0033291715001397. UCLA: Retrieved from: http://www.escholarship.org/uc/item/0535935x Psychological medicine, vol 45, iss 16 |
| ISSN: | 1469-8978 0033-2917 |
| DOI: | 10.1017/S0033291715001397. |
| Popis: | Background.Body dysmorphic disorder (BDD) and anorexia nervosa (AN) are both characterized by distorted perception of appearance. Previous studies in BDD suggest abnormalities in visual processing of own and others’ faces, but no study has examined visual processing of faces in AN, nor directly compared the two disorders in this respect.Method.We collected functional magnetic resonance imaging data on 60 individuals of equivalent age and gender in each of three groups – 20 BDD, 20 weight-restored AN, and 20 healthy controls (HC) – while they viewed images of others’ faces that contained only high or low spatial frequency information (HSF or LSF). We tested hypotheses about functional connectivity within specialized sub-networks for HSF and LSF visual processing, using psychophysiological interaction analyses.Results.The BDD group demonstrated increased functional connectivity compared to HC between left anterior occipital face area and right fusiform face area (FFA) for LSF faces, which was associated with symptom severity. Both BDD and AN groups had increased connectivity compared to HC between FFA and precuneous/posterior cingulate gyrus for LSF faces, and decreased connectivity between FFA and insula. In addition, we found that LSF connectivity between FFA and posterior cingulate gyrus was significantly associated with thoughts about own appearance in AN.Conclusions.Results suggest similar abnormal functional connectivity within higher-order systems for face processing in BDD and AN, but distinct abnormal connectivity patterns within occipito-temporal visual networks. Findings may have implications for understanding relationships between these disorders, and the pathophysiology underlying perceptual distortions. |
| Databáze: | OpenAIRE |
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