Plasma cholesterol and endogenous cholesterol synthesis during refeeding in anorexia nervosa
| Autor: | Christine Feillet-Coudray, François Feillet, Jean-Marie Bard, Michel Vidailhet, Bernard Kabuth, Elisabeth Favre, H J Parra, Jean-Charles Fruchart |
|---|---|
| Přispěvatelé: | ProdInra, Migration, Unité de recherche Maladies Métaboliques et Micronutriments (U3M), Institut National de la Recherche Agronomique (INRA) |
| Rok vydání: | 2000 |
| Předmět: |
medicine.medical_specialty
Anorexia Nervosa Adolescent Hydrocortisone Apolipoprotein B Diet therapy [SDV]Life Sciences [q-bio] Clinical Biochemistry Population Nutritional Status Lathosterol Biochemistry Body Mass Index Cholesterol Dietary Eating chemistry.chemical_compound Adrenocorticotropic Hormone Internal medicine Humans Prealbumin Medicine Child education Serum Albumin Triglycerides education.field_of_study Estradiol biology business.industry Cholesterol Body Weight Biochemistry (medical) General Medicine Metabolism Body Height [SDV] Life Sciences [q-bio] Hospitalization Apolipoproteins Endocrinology chemistry biology.protein Female lipids (amino acids peptides and proteins) business Body mass index Follow-Up Studies Lipoprotein |
| Zdroj: | Clinica Chimica Acta Clinica Chimica Acta, Elsevier, 2000, 294, pp.45-56 |
| ISSN: | 0009-8981 |
| Popis: | Normal or high levels of cholesterol have been measured in patients with anorexia nervosa (AN). Given that cholesterol intake in AN is usually very low, the reasons for this anomaly are not clearly understood. We studied lipid and lipoprotein profiles and endogenous cholesterol synthesis, estimated by serum lathosterol, in a population of 14 girls with AN, before and during a period of 30 days refeeding. The initial body mass index (BMI) of the patients was 13.41±1.62 kg/m 2 . No changes were observed during refeeding in endocrine parameters (ACTH, cortisol and estradiol). At Day 0 the lipids data measured here showed normal levels of triglycerides, and total cholesterol at the upper limits of the normal range (5.44±1 mmol/l). At this time, total and LDL cholesterol were negatively correlated with transthyretin and BMI. Serum lathosterol (a precursor in cholesterol synthesis pathway) increased significantly (5.99±1.75 (Day 0) vs. 8.39±2.96 (Day 30); P =0.02) while there was a significant decrease in apo B (0.79±0.33 (Day 0) vs. 0.60±0.17 g/l (Day 30), P =0.02) with refeeding. Thus, patients with initial high cholesterol levels have the worst nutritional status and high cholesterol levels are not related to a de novo synthesis. This profile returns to normal with refeeding. An increase of cellular cholesterol uptake may be responsible for this apparently paradoxical evolution with increase of cholesterol synthesis and decrease of apo B during renutrition. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect