Effect of immunoglobulin G on the responsiveness of human neutrophils to soluble staphylococcal protein A-induced neutrophil migration inhibition factor from T-lymphocytes
| Autor: | L G Wong, R Wistar, K K Colburn, R H Weisbart, R F Ashman |
|---|---|
| Rok vydání: | 1980 |
| Předmět: |
Neutrophils
T-Lymphocytes Phagocytosis Leukocyte Migration-Inhibitory Factors Immunology medicine.disease_cause Microbiology Immunoglobulin G Concanavalin A medicine Humans Staphylococcal Protein A Cells Cultured Lymphokines biology Lymphokine Antibody opsonization Myeloma Proteins Infectious Diseases Immunoglobulin M Staphylococcus aureus biology.protein Parasitology Antibody Research Article |
| Zdroj: | Infection and Immunity. 30:674-677 |
| ISSN: | 1098-5522 0019-9567 |
| DOI: | 10.1128/iai.30.3.674-677.1980 |
| Popis: | Staphylococcal protein A is a bacterial cell wall product that binds human immunoglobulin G and thereby interferes with opsonization and phagocytosis of Staphylococcus aureus by neutrophils. Phagocytic cells are also responsive to various non-immunoglobulin lymphocyte mediators. We utilized the detection of a newly recognized mediator, a neutrophil migration inhibition factor from T-lymphocytes (NIF-T), to show that aggregates of staphylococcal protein A and immunoglobulins G could inhibit the responsiveness of neutrophils to NIF-T. That such aggregates may alter the responsiveness of neutrophils to lymphocyte mediators that amplify or modulate phagocytic functions may have important pathogenetic implications in staphylococcal infection. |
| Databáze: | OpenAIRE |
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