HLA-G5 in the blood of leukemia patients and healthy individuals
| Autor: | Tatiana Železníková, Gustáv Russ, Katarina Polakova |
|---|---|
| Rok vydání: | 2013 |
| Předmět: |
Adult
Male Cancer Research Enzyme-Linked Immunosorbent Assay Disease Human leukocyte antigen Cell Line hemic and lymphatic diseases Humans Medicine Stage (cooking) Aged Aged 80 and over HLA-G Antigens business.industry Hematology Middle Aged medicine.disease Leukemia Lymphocytic Chronic B-Cell Leukemia Soluble hla Oncology Case-Control Studies Healthy individuals Immunology Female business |
| Zdroj: | Leukemia Research. 37:139-145 |
| ISSN: | 0145-2126 |
| DOI: | 10.1016/j.leukres.2012.10.019 |
| Popis: | In this work we focused on analysis of HLA-G5 molecules in the blood of patients with B-CLL leukemia and healthy individuals. Using sandwich ELISA, we found total soluble HLA-G, represented by sHLA-G1 and HLA-G5 in most of B-CLL patients while HLA-G5 alone was present only in few cases in both groups. These results lead us to assume that the majority of soluble HLA-G in blood is generated by proteolytic cleavage and shedding of membrane-bound HLA-G1. There is no correlation between the presence of HLA-G5 in blood of B-CLL patients and the stage of disease, age, and gender. |
| Databáze: | OpenAIRE |
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