Limitations of follicle-stimulating hormone in assessing menopause status: findings from the National Health and Nutrition Examination Survey (NHANES 1999-2000)*
| Autor: | Lester R. Curtin, Debra J. Brody, Steven C Kaufman, Jeffery P. Hughes, Janet B. Henrich |
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| Rok vydání: | 2006 |
| Předmět: |
Adult
endocrine system medicine.medical_specialty Multivariate analysis National Health and Nutrition Examination Survey Menopause Premature Physiology Sensitivity and Specificity Follicle-stimulating hormone Predictive Value of Tests medicine Humans Menopause Status Menstrual Cycle Gynecology business.industry Age Factors Obstetrics and Gynecology Luteinizing Hormone Middle Aged Nutrition Surveys medicine.disease United States Perimenopause Postmenopause Menopause Premenopause Predictive value of tests Multivariate Analysis Female Follicle Stimulating Hormone Luteinizing hormone business Biomarkers hormones hormone substitutes and hormone antagonists Hormone |
| Zdroj: | Menopause. 13:171-177 |
| ISSN: | 1072-3714 |
| DOI: | 10.1097/01.gme.0000198489.49618.96 |
| Popis: | Objective We used data from the National Health and Nutrition Examination Survey (NHANES 1999-2000) to: establish new population-based estimates for follicle-stimulating hormone (FSH) and luteinizing hormone (LH); identify factors associated with FSH; and assess its efficacy in distinguishing among women in the reproductive, menopause transition, and postmenopausal stages. Design Nationally representative sample of 576 women aged 35 to 60 years examined during NHANES 1999-2000. Results Levels of FSH and LH increased significantly with reproductive stage. (Geometric mean FSH levels for successive stages: reproductive, 7.0 mIU/mL, SE 0.4; menopause transition, 21.9 mIU/mL, SE 3.7; and postmenopause, 45.7 mIU/mL, SE 4.3). There was considerable overlap, however, among distributions of FSH by stage. Only age and reproductive stage were significantly associated with FSH in multivariable analysis. FSH cutoff points between the reproductive and menopause transition stages [FSH = 13 mIU/mL, sensitivity 67.4% (95% CI 50.0-81.1), specificity 88.1% (95% CI 81.1-92.8)] and between the menopause transition and postmenopause stages [FSH = 45 mIU/mL, sensitivity 73.6% (95% CI 60.1-83.7), specificity 70.6% (95% CI 52.4-84.0)] were neither sensitive nor very specific. Conclusions Age and reproductive stage are the most important determinants of FSH levels in US women; however, FSH by itself has limited utility in distinguishing among women in different reproductive stages. |
| Databáze: | OpenAIRE |
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