Clinical, biological, and histologic parameters as predictors of relapse in ulcerative colitis
| Autor: | Albert Cohen, Alain Bitton, A C Stevens, Michael D. De B. Edwardes, Mark A. Peppercorn, Athos Bousvaros, Samir A. Shah, Bernard J. Ransil, John L. Niles, Gary Wild, Donald A. Antonioli |
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| Rok vydání: | 2001 |
| Předmět: |
Adult
Male medicine.medical_specialty Blood Sedimentation Inflammatory bowel disease Gastroenterology Sex Factors Predictive Value of Tests Recurrence Internal medicine Humans Medicine Longitudinal Studies Prospective Studies Prospective cohort study Survival analysis Interleukin-15 Hepatology medicine.diagnostic_test Interleukin-6 business.industry Proportional hazards model Interleukins Hazard ratio Middle Aged medicine.disease Survival Analysis Ulcerative colitis Surgery C-Reactive Protein Predictive value of tests Erythrocyte sedimentation rate Multivariate Analysis Colitis Ulcerative Female business Biomarkers Follow-Up Studies Interleukin-1 |
| Zdroj: | Gastroenterology. 120:13-20 |
| ISSN: | 0016-5085 |
| DOI: | 10.1053/gast.2001.20912 |
| Popis: | Background & Aims: Ulcerative colitis (UC) is a chronic relapsing infammatory bowel disease. We aimed to assess whether clinical, biological, and histologic parameters in quiescent UC predict time to clinical relapse. Methods: Seventy-four patients with clinically and endoscopically determined inactive UC were followed up for 1 year or for a shorter period if they had a relapse. Serum erythrocyte sedimentation rate; C-reactive protein, interleukin (IL)-1β, IL-6, and IL-15 values; anti-neutrophil cytoplasmic antibody titers; and rectal biopsy specimens were obtained at baseline, at 6 and 12 months, and/or at relapse. Multivariate survival analysis was performed to determine independent predictors of clinical relapse. Results: Twenty-seven patients relapsed (19/42 women; 8/32 men). Multivariate Cox regression analysis retained younger age ( P = 0.003; hazard ratio, 0.4 per decade), greater number of prior relapses in women ( P P = 0.003; hazard ratio, 4.5) on rectal biopsy specimens as predictors of shorter time to clinical relapse. Kaplan–Meier survival curves showed the 20–30-year-old age group and women with more than 5 prior relapses to be groups with shorter times to relapse. Conclusions: Younger age, multiple previous relapses (for women), and basal plasmacytosis on rectal biopsy specimens were independent predictors of earlier relapse. These findings may help identify patients with inactive UC who will require optimal maintenance medical therapy. GASTROENTEROLOGY 2001;120:13-20 |
| Databáze: | OpenAIRE |
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