Incorporation of Stromal Cell-Derived Factor-1α in Three-Dimensional Hydroxyapatite/Polyacrylonitrile Composite Scaffolds for Bone Regeneration
| Autor: | Huifang Yang, Yeming Lu, Nanrui Hong, Lin Jin, Jiayan Li, Yan Li, Jieda Wang, Shuyi Wu |
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| Rok vydání: | 2018 |
| Předmět: |
Stromal cell
Chemistry 0206 medical engineering Biomedical Engineering Biomaterial 02 engineering and technology Bone healing 021001 nanoscience & nanotechnology 020601 biomedical engineering Cell biology Biomaterials Cell culture Progenitor cell Stem cell 0210 nano-technology Bone regeneration Homing (hematopoietic) |
| Zdroj: | ACS Biomaterials Science & Engineering. 5:911-921 |
| ISSN: | 2373-9878 |
| DOI: | 10.1021/acsbiomaterials.8b01146 |
| Popis: | Bone regeneration strategies rely on biomaterial constructs with stem cells or growth factors. By comparison, cell homing strategies employ chemokines to recruit the host endogenous stem or progenitor cells to the defect site to support endogenous healing. In the present study, we used a novel fluffy hydroxyapatite/polyacrylonitrile (HA/PAN) composite scaffold to provide a better three-dimensional cell culture microenvironment. These HA/PAN composite scaffolds loaded with stromal cell-derived factor-1α (SDF-1α) provided a diffusion-controlled SDF-1α release profile and endowed the scaffolds with cell homing capabilities. Furthermore, the scaffolds significantly stimulated bone marrow stromal cell (BMSC) recruitment, facilitated BMSC osteogenic differentiation, and promoted ectopic bone formation. Our results suggest that a HA/PAN composite scaffold loaded with SDF-1α offers a clinically beneficial bone repair strategy. |
| Databáze: | OpenAIRE |
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