Prolonged CD4+ Lymphocytopenia and Thrombocytopenia in a Chimpanzee Persistently Infected with Human Immunodeficiency Virus Type 1
| Autor: | Mawle Ac, Harold M. McClure, Stricker Rb, Swenson Rb, Daniel C. Anderson, Patricia N. Fultz, Anne R. Brodie, Rebecca L. Siegel |
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| Rok vydání: | 1991 |
| Předmět: |
CD4-Positive T-Lymphocytes
Male Time Factors Pan troglodytes Lymphocyte T cell Autoimmunity HIV Infections Cross Reactions HIV Antibodies Histones Lymphopenia Immunopathology Complement C4b medicine Animals Immunology and Allergy Immunity Cellular biology Antibody titer Complement C4 medicine.disease Thrombocytopenia Virology Peptide Fragments Infectious Diseases medicine.anatomical_structure Immunology HIV-1 biology.protein Viral disease Antibody Lymphocytopenia CD8 |
| Zdroj: | Journal of Infectious Diseases. 163:441-447 |
| ISSN: | 1537-6613 0022-1899 |
| DOI: | 10.1093/infdis/163.3.441 |
| Popis: | The immunologic and virologic status of a chimpanzee inoculated with multiple isolates of the human immunodeficiency virus type 1 (HIV-1) were assessed over 57 months to determine whether prolonged thrombocytopenia and CD4+ lymphocytopenia observed in the animal might be associated with long-term HIV infection. Although the chimpanzee showed no signs of disease, it lost both CD4+ (as low as 134 cells/microliter) and CD8+ lymphocytes approximately 30 months after initial infection, followed by thrombocytopenia that has persisted for greater than 2 years. Lymphopenia and thrombocytopenia were preceded by or coincided with the appearance of antibodies cross-reactive with histone H2B and decreased levels of complement component C4; an eightfold decrease in HIV-specific antibody titers; the inability of CD8+ lymphocytes to suppress virus replication; impaired proliferative responses to T cell mitogens; and the isolation of cell-free HIV from plasma. These data suggest that, given sufficient time, HIV-infected chimpanzees may develop disease. |
| Databáze: | OpenAIRE |
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