Prognostic Role of Cardiac Magnetic Resonance in Arrhythmogenic Right Ventricular Cardiomyopathy

Autor: Elisabetta Strata, Raffaella Gaeta, Adriana Pantano, Gianluca Di Bella, Gianfranco Sinagra, Giovanni Donato Aquaro, Raffaele De Caterina, Alessandro Altinier, Michele Emdin, Paolo Piaggi, C Grigoratos, Alessandro Pingitore
Přispěvatelé: Aquaro, Giovanni Donato, Pingitore, Alessandro, Di Bella, Gianluca, Piaggi, Paolo, Gaeta, Raffaella, Grigoratos, Crysantho, Altinier, Alessandro, Pantano, Adriana, Strata, Elisabetta, De Caterina, Raffaele, Sinagra, Gianfranco, Emdin, Michele
Rok vydání: 2018
Předmět:
Adult
Male
medicine.medical_specialty
Heart Ventricles
medicine.medical_treatment
Population
Magnetic Resonance Imaging
Cine
030204 cardiovascular system & hematology
Ventricular tachycardia
Right ventricular cardiomyopathy
030218 nuclear medicine & medical imaging
Sudden cardiac death
03 medical and health sciences
0302 clinical medicine
Predictive Value of Tests
Internal medicine
medicine
Humans
Prospective Studies
cardiovascular diseases
education
Arrhythmogenic Right Ventricular Dysplasia
education.field_of_study
medicine.diagnostic_test
business.industry
Reproducibility of Results
Stroke Volume
Magnetic resonance imaging
Prognosis
medicine.disease
Implantable cardioverter-defibrillator
Predictive value of tests
Shock (circulatory)
cardiovascular system
Cardiology
Female
medicine.symptom
Cardiology and Cardiovascular Medicine
business
Follow-Up Studies
Zdroj: The American Journal of Cardiology. 122:1745-1753
ISSN: 0002-9149
DOI: 10.1016/j.amjcard.2018.08.007
Popis: We sought to evaluate the prognostic role of cardiac magnetic resonance (CMR) in patients with definite, borderline and possible diagnosis of arrhythmogenic right ventricular cardiomyopathy (ARVC) as defined by the International Task Force (TF) in 2010. CMR was performed in 175 patients: 52 with definite, 50 with borderline and 73 possible ARVC. Abnormal-CMR was defined as the presence of ≥1 CMR abnormalities (including abnormalities of right ventricular and left ventricular wall motion, fat infiltration, late gadolinium enhancement, dilation and dysfunction of either ventricles). During the follow-up time 35 patients had hard cardiac events (sudden cardiac death, appropriate implantable cardioverter defibrillator shock and resuscitated cardiac arrest), and 34 of them occurred in patients with abnormal-CMR (negative predictive value = 96.9%). At the multivariate Cox-regression analysis LV involvement at CMR (fat infiltration and/or late gadolinium enhancement), and episode of nonsustained ventricular tachycardia (NSVT) were independent predictors of cardiac events in both the whole population (LV involvement: HR 3.69, 95% CI 1.57-8.65, p = 0.0002; NSVT: HR 5.8, 95% CI 2.82-11.9, p < 0.0001), and in the group of patients with definite ARVC (LV involvement: HR 3.03, 95% CI 1.15 to 8.02, p = 0.02; NSVT: HR 12.1, 95% CI 4.02-36.5, p < 0.0001). In conclusion, CMR evidence of LV involvement is a strong independent predictor of cardiac events in patients with definite, borderline or possible ARVC diagnosis. Abnormal CMR has very high negative predictive value for hard cardiac events
Databáze: OpenAIRE
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