Tumour-suppressive role of PTPN13 in hepatocellular carcinoma and its clinical significance

Autor: Kai Zhu, Jia Fan, Ai-Wu Ke, Chu-Bin Luo, Zhi-Qiang Hu, Qiman Sun, Hao Zhan, Bo Hu, Jian Zhou, Jin-Wu Hu, Jia-Hao Jiang, Xiao-Wu Huang, Chao Sun
Rok vydání: 2016
Předmět:
Male
0301 basic medicine
MAPK/ERK pathway
Oncology
medicine.medical_specialty
Carcinoma
Hepatocellular
Epithelial-Mesenchymal Transition
MAP Kinase Signaling System
Protein Tyrosine Phosphatase
Non-Receptor Type 13
Biology
Metastasis
03 medical and health sciences
0302 clinical medicine
Cell Movement
Cell Line
Tumor
Internal medicine
medicine
Humans
Genes
Tumor Suppressor
Neoplasm Invasiveness
Clinical significance
Epithelial–mesenchymal transition
neoplasms
Cell Proliferation
Cell growth
Liver Neoplasms
Hep G2 Cells
General Medicine
Middle Aged
Prognosis
medicine.disease
digestive system diseases
Hedgehog signaling pathway
Gene Expression Regulation
Neoplastic
030104 developmental biology
PTPN13
030220 oncology & carcinogenesis
Hepatocellular carcinoma
Cancer research
Female
Signal Transduction
Zdroj: Tumor Biology. 37:9691-9698
ISSN: 1423-0380
1010-4283
Popis: Hepatocellular carcinoma (HCC) is the second leading cause of cancer mortality and carries a dismal prognosis. The present study aimed to identify the tumour-suppressive role and clinical implications of PTPN13 in HCC progression. We tested the effects of PTPN13 expression in proliferation, invasion, epithelial-mesenchymal transition and associated pathways in HCC cell lines in vitro. Furthermore, its clinical relevance was evaluated in a tissue microarray analysis of samples from 282 HCC patients. Various HCC cell lines expressed relatively low PTPN13 protein levels in vitro. PTPN13 overexpression significantly inhibited the progression of HCC cells, possibly by inhibiting epithelial-mesenchymal transition through inactivation of the EGFR/ERK signalling pathway. Tissue microarray analysis revealed that high PTPN13 expression was correlated with a favourable prognosis in postoperative HCC patients. This study demonstrated the tumour suppressor, PTPN13, as an alternative therapeutic target for HCC.
Databáze: OpenAIRE
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