Tumour-suppressive role of PTPN13 in hepatocellular carcinoma and its clinical significance
Autor: | Kai Zhu, Jia Fan, Ai-Wu Ke, Chu-Bin Luo, Zhi-Qiang Hu, Qiman Sun, Hao Zhan, Bo Hu, Jian Zhou, Jin-Wu Hu, Jia-Hao Jiang, Xiao-Wu Huang, Chao Sun |
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Rok vydání: | 2016 |
Předmět: |
Male
0301 basic medicine MAPK/ERK pathway Oncology medicine.medical_specialty Carcinoma Hepatocellular Epithelial-Mesenchymal Transition MAP Kinase Signaling System Protein Tyrosine Phosphatase Non-Receptor Type 13 Biology Metastasis 03 medical and health sciences 0302 clinical medicine Cell Movement Cell Line Tumor Internal medicine medicine Humans Genes Tumor Suppressor Neoplasm Invasiveness Clinical significance Epithelial–mesenchymal transition neoplasms Cell Proliferation Cell growth Liver Neoplasms Hep G2 Cells General Medicine Middle Aged Prognosis medicine.disease digestive system diseases Hedgehog signaling pathway Gene Expression Regulation Neoplastic 030104 developmental biology PTPN13 030220 oncology & carcinogenesis Hepatocellular carcinoma Cancer research Female Signal Transduction |
Zdroj: | Tumor Biology. 37:9691-9698 |
ISSN: | 1423-0380 1010-4283 |
Popis: | Hepatocellular carcinoma (HCC) is the second leading cause of cancer mortality and carries a dismal prognosis. The present study aimed to identify the tumour-suppressive role and clinical implications of PTPN13 in HCC progression. We tested the effects of PTPN13 expression in proliferation, invasion, epithelial-mesenchymal transition and associated pathways in HCC cell lines in vitro. Furthermore, its clinical relevance was evaluated in a tissue microarray analysis of samples from 282 HCC patients. Various HCC cell lines expressed relatively low PTPN13 protein levels in vitro. PTPN13 overexpression significantly inhibited the progression of HCC cells, possibly by inhibiting epithelial-mesenchymal transition through inactivation of the EGFR/ERK signalling pathway. Tissue microarray analysis revealed that high PTPN13 expression was correlated with a favourable prognosis in postoperative HCC patients. This study demonstrated the tumour suppressor, PTPN13, as an alternative therapeutic target for HCC. |
Databáze: | OpenAIRE |
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