Effects of intermittent hypoxia on sympathetic activity and blood pressure in humans
| Autor: | Urs A, Leuenberger, Derick, Brubaker, Sadeq A, Quraishi, Sadeq, Quraishi, Cynthia S, Hogeman, Virginia A, Imadojemu, Kristen S, Gray |
|---|---|
| Rok vydání: | 2005 |
| Předmět: |
Adult
Male Mean arterial pressure Sympathetic Nervous System Time Factors Apnea Blood Pressure Cellular and Molecular Neuroscience Heart Rate medicine Humans Hypoxia Endocrine and Autonomic Systems business.industry Muscles Respiration Intermittent hypoxia Microneurography Middle Aged Hypoxia (medical) medicine.disease respiratory tract diseases Oxygen Obstructive sleep apnea Blood pressure Anesthesia Female Neurology (clinical) medicine.symptom business Hypercapnia |
| Zdroj: | Autonomic Neuroscience. 121:87-93 |
| ISSN: | 1566-0702 |
| DOI: | 10.1016/j.autneu.2005.06.003 |
| Popis: | Sympathetic nerve activity and arterial pressure are frequently elevated in patients with obstructive sleep apnea (OSA). The mechanisms responsible for chronic sympathetic activation and hypertension in OSA are unknown. To determine whether repetitive apneas raise sympathetic nerve activity and/or arterial pressure, awake and healthy young subjects performed voluntary end-expiratory apneas for 20 s per min for 30 min (room air apneas). To accentuate intermittent hypoxia, in a separate group of subjects, hypoxic gas (inspired O2 10%) was added to the inspiratory port for 20 s before each apnea (hypoxic apneas). Mean arterial pressure (MAP) and muscle sympathetic nerve activity (MSNA, peroneal microneurography) were determined before and up to 30 min following the repetitive apneas. Following 30 hypoxic apneas (O2 saturation nadir 83.1+/-1.2%), MSNA increased from 17.4+/-2.7 to 23.4+/-2.5 bursts/min and from 164+/-28 to 240+/-35 arbitrary units respectively (P |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect