Isoniazid Levels in the Bronchoalveolar Lavage Fluid of Patients with Pulmonary Tuberculosis
| Autor: | Timothy J. Harkin, M. E. Doerfler, J. K. O'Brien, William N. Rom |
|---|---|
| Rok vydání: | 1998 |
| Předmět: |
Adult
Male Pulmonary and Respiratory Medicine Pathology medicine.medical_specialty Tuberculosis First line Pulmonary tuberculosis Isoniazid medicine Humans heterocyclic compounds In patient Tuberculosis Pulmonary Aged medicine.diagnostic_test business.industry Middle Aged biochemical phenomena metabolism and nutrition respiratory system Serum concentration bacterial infections and mycoses medicine.disease respiratory tract diseases Radiography Bronchoalveolar lavage Female business Bronchoalveolar Lavage Fluid Protein concentration medicine.drug |
| Zdroj: | Lung. 176:205-211 |
| ISSN: | 0341-2040 |
| DOI: | 10.1007/pl00007603 |
| Popis: | Isoniazid (INH) is one of the most important first line drugs in the treatment of tuberculosis. We utilized high performance liquid chromatography with a hydrazone extraction technique to measure INH in bronchoalveolar lavage (BAL) fluid specimens from six patients with active pulmonary tuberculosis. We found BAL fluid INH levels to be similar to 2-h peak serum levels. The concentration of INH in BAL fluid from lobes with infiltrate was similar to the concentration of INH in BAL fluid from lobes without infiltrate (0.062 microgram/ml and 0.073 microgram/ml, respectively). After adjusting for protein concentration in the BAL fluid, INH levels in lobes with infiltrate were threefold lower than in lobes without infiltrate. The correlation between the concentration of INH in serum and BAL fluid approached significance after correcting for protein (lobes with infiltrate, r2 = 0.60 (p = 0.07); lobes without infiltrate, r2 = 0.50 (p = 0.12). INH penetrates into bronchoalveolar fluid, and concentrations of INH in the BAL fluid suggest that assessment of the INH serum concentration is adequate to evaluate bioavailability of the drug in patients with pulmonary tuberculosis. |
| Databáze: | OpenAIRE |
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