Optimal Antigens for HIV Vaccines Based on CD8+ T Response, Protein Length, and Sequence Variability
| Autor: | Michael R. Betts, Richard A. Koup, Karina Yusim |
|---|---|
| Rok vydání: | 2002 |
| Předmět: |
CD4-Positive T-Lymphocytes
viruses T cell Gene Products gag HIV Infections CD8-Positive T-Lymphocytes Biology Gene Products nef Cohort Studies Interferon-gamma Immune system Antigen Genetics medicine Humans nef Gene Products Human Immunodeficiency Virus Antigens HIV vaccine Protein length Molecular Biology Sequence (medicine) AIDS Vaccines Immunogenicity Genetic Variation virus diseases Cell Biology General Medicine Virology medicine.anatomical_structure Immunology CD8 |
| Zdroj: | DNA and Cell Biology. 21:665-670 |
| ISSN: | 1557-7430 1044-5498 |
| Popis: | The identification of optimal antigens to include in an HIV vaccine designed to elicit a cellular immune response requires careful consideration of protein length, variability, and immunogenicity. Here, we have examined the relationship of these parameters in a cohort of HIV-infected subjects. We find that HIV Gag and Nef represent optimal antigens for the CD8+ T cell response, based on size, variability, and immunogenicity. Although the Env and Pol proteins have a poorer response to length (Pol) or variability (Env) ratio than Gag or Nef, they are still strong candidates for inclusion into an HIV vaccine, based on overall response frequency in the cohort. The accessory proteins Tat, Rev, Vif, Vpr, and Vpu in general all elicit very low CD8+ T cell responses, and this, in combination with their high variability, makes them less attractive as vaccine antigens. |
| Databáze: | OpenAIRE |
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