Maternal caregiving and DNA methylation in human infants and children: Systematic review
| Autor: | Renato Borgatti, Livio Provenzi, Rosario Montirosso, Giunia Scotto di Minico, Maddalena Brambilla |
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| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Behavioral epigenetics Web of science Quantitative Trait Loci Locus (genetics) Developmental research Developmental psychology Epigenome 03 medical and health sciences Behavioral Neuroscience 0302 clinical medicine Animal model Genetics Humans Medicine Epigenetics Child Maternal Behavior business.industry Infant Newborn Infant Methylation DNA Methylation Mother-Child Relations 030104 developmental biology Neurology Child Preschool DNA methylation Female business 030217 neurology & neurosurgery |
| Zdroj: | Genes, Brain and Behavior. 19 |
| ISSN: | 1601-183X 1601-1848 |
| DOI: | 10.1111/gbb.12616 |
| Popis: | The integration of behavioral epigenetics' principles (eg, DNA methylation) into the study of human infants' development has mainly focused on the effects of early adverse exposures, paying less attention to protective caregiving experiences. The present review focused on DNA methylation linked to variations in maternal behavior in human infants and children. Literature search occurred on three databases (PubMed, Scopus and Web of Science) and 11 records were selected. Key variables were abstracted from each article including: sample size and characteristics, time and type of maternal caregiving behavior exposure, time and locus of methylation biomarker, presence/absence, time and type of adverse exposure. Six out of eleven records documented the predictive effect of maternal caregiving on DNA methylation, whereas the remaining five reported on the role of maternal behavior as an influencing factor of the adversity-to-methylation link. Consistent with evidence from the animal model, the quality of maternal caregiving in humans (a) might be associated with variations in DNA methylation status of specific genes involved in socio-emotional development and (b) might partially buffer the association between early adversities and epigenetic variations in infants and children. Current evidence suggests that the quality of maternal caregiving can contribute to behavioral development trajectories of human infants and children at least partially through epigenetic regulation. Open questions and methodological aspects are discussed to guide future human developmental research in behavioral epigenetics. |
| Databáze: | OpenAIRE |
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