The Association between Fever and Prognosis in Lung Cancer Patients with Bone Metastases Receiving Zoledronic Acid

Autor: Mari Kogo, Noriko Takahashi, Tadanori Sasaki, Mayumi Higashino, Mitsuki Matsui, Fumio Kokubu, Tomiko Sunaga, Tomomi Hozumi, Shoko Nakamura, Akiko Nagatani, Kazushi Shimamoto
Rok vydání: 2017
Předmět:
0301 basic medicine
Oncology
Male
Lung Neoplasms
Bone disease
medicine.medical_treatment
Kaplan-Meier Estimate
Zoledronic Acid
chemistry.chemical_compound
0302 clinical medicine
Drug Discovery
Leukocytes
Pharmacology (medical)
Aged
80 and over
Bone Density Conservation Agents
Diphosphonates
Hazard ratio
Imidazoles
General Medicine
Middle Aged
Prognosis
Infectious Diseases
medicine.anatomical_structure
030220 oncology & carcinogenesis
Cohort
Female
medicine.drug
Adult
medicine.medical_specialty
Neutropenia
Fever
Bone Neoplasms
Drug Administration Schedule
03 medical and health sciences
Internal medicine
White blood cell
Lactate dehydrogenase
medicine
Humans
Lung cancer
Aged
Proportional Hazards Models
Retrospective Studies
Pharmacology
Chemotherapy
L-Lactate Dehydrogenase
business.industry
medicine.disease
030104 developmental biology
Zoledronic acid
chemistry
business
Zdroj: Chemotherapy. 62(6)
ISSN: 1421-9794
Popis: Zoledronic acid is an established agent used in the management of metastatic bone disease. The administration of zoledronic acid improves overall survival (OS) of lung cancer patients with bone metastases receiving chemotherapy. However, it is currently unknown whether zoledronic acid-induced fever is associated with OS. The purpose of this study was to examine the association between zoledronic acid-induced fever and prognosis in lung cancer patients with bone metastases. We retrospectively analyzed 98 lung cancer patients with bone metastases who had received zoledronic acid. The end point outcome measure was OS. Multivariate analyses were used to estimate the hazard ratio (HR) for OS due to fever after adjusting for covariates. In multivariate analysis, white blood cell (WBC) count, lactate dehydrogenase (LDH) level, fever, chemotherapy, and hypercalcemia were independent prognostic factors, with HRs of 2.834 for WBC count (3/μL vs. ≥10 × 103/μL, p < 0.001), 3.044 for LDH level (p < 0.001), 0.603 for fever (p = 0.039), 0.481 for chemotherapy (chemotherapy not administered vs. administered, p = 0.006), and 2.453 for hypercalcemia (p = 0.001). Zoledronic acid-induced fever was the most important prognostic factor in this cohort of lung cancer patients with bone metastases.
Databáze: OpenAIRE
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