Markers of haemostasis and angiogenesis in placentae from gestational vascular complications: Impairment of mechanisms involved in maintaining intervillous blood flow

Autor: Elena Chinni, Elvira Grandone, Giovanni Luca Tiscia, Maria Matteo, Donatella Colaizzo, Maurizio Margaglione, Pasquale Martinelli, Giuseppe Maria Maruotti
Přispěvatelé: Chinni, E, Colaizzo, D, Tiscia, Gl, Martinelli, Pasquale, Maruotti, Gm, Matteo, M, Margaglione, M, Grandone, E.
Rok vydání: 2010
Předmět:
Zdroj: Thrombosis Research. 125:267-271
ISSN: 0049-3848
DOI: 10.1016/j.thromres.2009.09.024
Popis: Introduction Preeclampsia (PE) and fetal growth restriction (FGR) are multifactorial diseases, whose pathogenesis is largely unknown. A significant relationship between haemostasis and angiogenesis in placentae from uneventful pregnancies was previously shown. Materials and Methods RNA expression of haemostasis (TF, TFPI, TFPI-2, PAI-2, Anx V, TM) and angiogenesis (Ang-1, Ang-2, PlGF, VEGF) markers in placentae from PE (n = 12), PE+FGR (n = 17) and FGR (n = 20) in respect of placentae from uncomplicated pregnancies (n = 21) were investigated. Results Placentae from complicated pregnancies showed a significant lower expression (p ≤ 0.05 Mann-Whitney U test) of TF, TFPI, TFPI-2, Anx V, PAI-2 than those from in uncomplicated ones. VEGF and PlGF were not different in the considered groups; Ang-1 and Ang-2 were significantly higher (p ≤ 0.05 Mann-Whitney U test) in the PE group. Correlations between factors involved in haemostasis and those involved in angiogenesis, observed in placentae from uneventful pregnancies are lacking in those from complicated ones. Conclusions Haemostasis factors are reduced in placentae from complicated pregnancies. The relationship between haemostasis and angiogenesis observed in uncomplicated pregnancies is impaired in PE and FGR.
Databáze: OpenAIRE