Success and failure of artesunate treatment in five transplant recipients with disease caused by drug-resistant cytomegalovirus

Autor: Patrice Morand, Raphaëlle Germi, Paolo Malvezzi, A. Thiebaut, O. Epaulard, Julien Lupo, Sophie Alain, C. Mariette, C. Saint Raymond, J. P. Brion
Přispěvatelé: Unit for Virus Host-Cell Interactions [Grenoble] (UVHCI), Centre National de la Recherche Scientifique (CNRS)-European Molecular Biology Laboratory [Grenoble] (EMBL)-Université Joseph Fourier - Grenoble 1 (UJF), Centre de Recherche Jean-Pierre AUBERT Neurosciences et Cancer - U1172 Inserm - U837 (JPArc), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Lille Nord de France (COMUE)-Université de Lille, Service de Bactériologie, Virologie, Hygiène [CHU Limoges], CHU Limoges, Molécules bioactives, conception, isolement et synthèse (MBCIS), Université Paris-Sud - Paris 11 (UP11)-Centre National de la Recherche Scientifique (CNRS), Service des Maladies Infectieuses, CHU Grenoble, Université Joseph Fourier - Grenoble 1 (UJF)-European Molecular Biology Laboratory [Grenoble] (EMBL)-Centre National de la Recherche Scientifique (CNRS), Centre de Recherche Jean-Pierre AUBERT Neurosciences et Cancer - U837 (JPArc), Université Lille Nord de France (COMUE)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lille
Jazyk: angličtina
Rok vydání: 2014
Předmět:
Male
Foscarnet
Artesunate
Cytomegalovirus
Drug resistance
chemistry.chemical_compound
MESH: Treatment Outcome
0303 health sciences
MESH: Middle Aged
MESH: Drug Resistance
Viral
[SDV.BBM.BS]Life Sciences [q-bio]/Biochemistry
Molecular Biology/Structural Biology [q-bio.BM]
Hematopoietic Stem Cell Transplantation
virus diseases
MESH: Transplantation
Middle Aged
Viral Load
Artemisinins
3. Good health
Treatment Outcome
Cytomegalovirus Infections
Female
MESH: Viral Load
medicine.drug
Cidofovir
Ganciclovir
MESH: Antiviral Agents
MESH: Cytomegalovirus
Congenital cytomegalovirus infection
MESH: Organ Transplantation
Antiviral Agents
03 medical and health sciences
Virology
Drug Resistance
Viral
MESH: Artemisinins
medicine
Humans
MESH: Hematopoietic Stem Cell Transplantation
030304 developmental biology
Pharmacology
Transplantation
MESH: Humans
030306 microbiology
business.industry
Organ Transplantation
MESH: Cytomegalovirus Infections
medicine.disease
MESH: Male
Multiple drug resistance
chemistry
Immunology
business
MESH: Female
Zdroj: Antiviral Research
Antiviral Research, Elsevier Masson, 2014, 101, pp.57-61
Antiviral Research, 2014, 101, pp.57-61
ISSN: 0166-3542
Popis: International audience; Cytomegalovirus (CMV) strains resistant to ganciclovir, cidofovir and/or foscarnet were genotypically and phenotypically characterised in two haematopoietic stem cell transplant recipients and three solid-organ transplant recipients with CMV disease. The anti-malaria drug artesunate led to a favourable virological and clinical response in three cases with mild CMV diseases (fever and neutropaenia) but was ineffective in two fatal CMV diseases with lung involvement in spite of a decrease in the CMV DNA load in blood and bronchoalveolar fluid.
Databáze: OpenAIRE
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