Ten-year incidence of Chagas cardiomyopathy among asymptomatic Trypanosoma cruzi-seropositive former blood donors
| Autor: | Sabino, Ester C, Ribeiro, Antonio L, Salemi, Vera MC, Di Lorenzo Oliveira, Claudia, Antunes, Andre P, Menezes, Marcia M, Ianni, Barbara M, Nastari, Luciano, Fernandes, Fabio, Patavino, Giuseppina M, Sachdev, Vandana, Capuani, Ligia, de Almeida-Neto, Cesar, Carrick, Danielle M, Wright, David, Kavounis, Katherine, Goncalez, Thelma T, Carneiro-Proietti, Anna Barbara, Custer, Brian, Busch, Michael P, Murphy, Edward L, National Heart, Lung, and Blood Institute Retrovirus Epidemiology Donor Study-II (REDS-II), International Component |
|---|---|
| Rok vydání: | 2013 |
| Předmět: |
Chagas Cardiomyopathy
Male Chagas disease Time Factors Blood Donors Disease Cardiorespiratory Medicine and Haematology Cardiovascular Cohort Studies and Blood Institute Retrovirus Epidemiology Donor Study-II (REDS-II) Lung International Component biology Incidence (epidemiology) Incidence Middle Aged Penetrance Infectious Diseases Heart Disease Cardiology Public Health and Health Services medicine.symptom Cardiology and Cardiovascular Medicine Brazil Adult medicine.medical_specialty Trypanosoma cruzi Clinical Sciences Asymptomatic Young Adult Rare Diseases Clinical Research Physiology (medical) Internal medicine parasitic diseases medicine Humans Retrospective Studies business.industry and Blood Institute Retrovirus Epidemiology Donor Study-II Retrospective cohort study National Heart biology.organism_classification medicine.disease Vector-Borne Diseases Good Health and Well Being Cardiovascular System & Hematology Asymptomatic Diseases Trypanosoma business Follow-Up Studies |
| Zdroj: | Circulation, vol 127, iss 10 |
| Popis: | Background— Very few studies have measured disease penetrance and prognostic factors of Chagas cardiomyopathy among asymptomatic Trypanosoma cruzi –infected persons. Methods and Results— We performed a retrospective cohort study among initially healthy blood donors with an index T cruzi –seropositive donation and age-, sex-, and period-matched seronegatives in 1996 to 2002 in the Brazilian cities of São Paulo and Montes Claros. In 2008 to 2010, all subjects underwent medical history, physical examination, ECGs, and echocardiograms. ECG and echocardiogram results were classified by blinded core laboratories, and records with abnormal results were reviewed by a blinded panel of 3 cardiologists who adjudicated the outcome of Chagas cardiomyopathy. Associations with Chagas cardiomyopathy were tested with multivariate logistic regression. Mean follow-up time between index donation and outcome assessment was 10.5 years for the seropositives and 11.1 years for the seronegatives. Among 499 T cruzi seropositives, 120 (24%) had definite Chagas cardiomyopathy, and among 488 T cruzi seronegatives, 24 (5%) had cardiomyopathy, for an incidence difference of 1.85 per 100 person-years attributable to T cruzi infection. Of the 120 seropositives classified as having Chagas cardiomyopathy, only 31 (26%) presented with ejection fraction P 3 heart sound. Conclusions— There is a substantial annual incidence of Chagas cardiomyopathy among initially asymptomatic T cruzi –seropositive blood donors, although disease was mild at diagnosis. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|