Cyclophilin D regulates lifespan and protein expression of aging markers in the brain of mice
| Autor: | Issa Pour-Ghaz, Dóra Zelena, Christos Chinopoulos, Josef J. Mansour, Ottó Pintér, Ibolya Bodnár, Vera Adam-Vizi, Erzsébet Oszwald, Viktoria Vereczki |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Male medicine.medical_specialty Aging Biology Protein expression 03 medical and health sciences Cyclophilins Gene Knockout Techniques 0302 clinical medicine Prosencephalon Internal medicine medicine Animals Humans Molecular Biology Transition (genetics) Behavior Animal Gene Expression Profiling Cell Biology Molecular biology Cyclophilin D Mice Inbred C57BL 030104 developmental biology Endocrinology Forebrain Molecular Medicine Metabotropic glutamate receptor 1 Female 030217 neurology & neurosurgery |
| Zdroj: | Mitochondrion. 34 |
| ISSN: | 1872-8278 |
| Popis: | Cyclophilin D (cypD) modulates the properties of the permeability transition pore, a phenomenon implicated in the manifestation of many diseases including aging. Here, we examined the effects of partial or complete deletion of cypD on i) lifespan, ii) forebrain protein expression of 18 aging markers as well as regional expression of GFAP, mGluR1, and alpha-synuclein, and iii) behaviour of aged (>24month) male and female mice. Both male and female cypD heterozygous but not KO mice exhibited increased lifespans compared to WT littermates, associated with alterations in the protein expression of some markers, albeit without exhibiting changes in behaviour. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect