Anamnestic, clinical and laboratory features of the acute period of ischemic stroke in young patients

Autor: Gusev, V. V., Kovtun, O. P., Lvova, O. A., Partylova, E. A., Sergeev, A. P., Sergeeva, M. V., Yanchuk, I. T., Dobrazova, D. A., Suvorkov, P. A., Shamalov, N. A.
Rok vydání: 2022
Předmět:
FIBRINOGEN BETA
GENETIC VARIABILITY
PARALYSIS
SINGLE NUCLEOTIDE SUBSTITUTIONS
MAJOR CLINICAL STUDY
UNCLASSIFIED DRUG
CLINICAL FEATURE
BETA3 INTEGRIN
ATRIAL FIBRILLATION
COMPUTER ASSISTED TOMOGRAPHY
HYPERLIPIDEMIA
CEREBROVASCULAR MALFORMATION
PARESIS
HUMAN
RISK FACTOR
BRACHIOCEPHALIC ARTERY STENOSIS
FEMALE
Psychiatry and Mental health
Clinical Psychology
METABOLIC DISORDER
BRAIN VASCULITIS
MIGRAINE
HOSPITALIZATION
RISK FACTORS
ISCHEMIC STROKE
ATHEROSCLEROTIC PLAQUE
BLOOD CLOTTING FACTOR 7
NUCLEIC ACID BASE SUBSTITUTION
HEART LEFT VENTRICLE HYPERTROPHY
BLOOD CLOTTING FACTOR 5
PLASMINOGEN ACTIVATOR INHIBITOR 1
COHORT ANALYSIS
GENETIC PREDISPOSITION
BRAIN INFARCTION
HETEROZYGOTE
NUCLEAR MAGNETIC RESONANCE IMAGING
ADULT
DNA POLYMORPHISM
MITRAL VALVE PROLAPSE
DYSLIPOPROTEINEMIA
ALPHA2 INTEGRIN
ARTICLE
FIBRINOGEN
ERYTHROCYTE SEDIMENTATION RATE
HOSPITAL ADMISSION
MALE
OCCLUSIVE CEREBROVASCULAR DISEASE
SPEECH DISORDER
YOUNG AGE
CONTROLLED STUDY
ANAMNESIS
INTENSIVE CARE
THROMBOPHILIA
Neurology (clinical)
RANKIN SCALE
SELF CARE
Zdroj: Nevrologiya, Neiropsikhiatriya, Psikhosomatika
ISSN: 2310-1342
2074-2711
DOI: 10.14412/2074-2711-2022-3-12-18
Popis: Objective: to study the anamnestic, clinical and laboratory features of the acute period of ischemic stroke (IS) and to determine the risk factors for its development in young patients.Patients and methods. Clinical and statistical processing of data of 256 patients aged 18 to 44 years included, who had IS, confirmed by computed and/or magnetic resonance imaging of the brain in the acute period, was carried out. Furthermore, in 154 patients and in 117 healthy participants, who made up the control group, eight polymorphisms of the thrombophilic spectrum genes were determined – FGB: -455G>A, F2: 20210G>A, F5: 1691G>A, F7: 10976G>A, F13: 103 G>T, ITGA2: 807C>T, ITGB3: 1565 T>C, PAI-1: -675 5G>4G.Results and discussion. 154 (60.15%) patients demonstrated good recovery (achievement of a level of ≤2 points on the Rankin scale by the patient). None of the patients died during their hospitalization. In the evaluated group of patients, we identified allelic variants of the thrombophilic spectrum genes and gene-gene combinations, the carriage of which increased the likelihood of IS development at the young age by 1.74 and 2.19 times, respectively. Taking into consideration additional examination methods, the pathogenetic variant of IS according to the TOAST classification was verified in 226 (88%) patients.Conclusion. In IS at a young age a detailed assessment of risk factors is required, including an analysis of carrier variants and combinations of procoagulant and prothrombotic spectrum gene polymorphisms.
Databáze: OpenAIRE
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