Reoperation with Total Hysterectomy after Incomplete Surgery Is Helpful in Patients with Incidentally Diagnosed Uterine Leiomyosarcoma
| Autor: | Ziting Li, Xiaohua Wu, Zhihong Han, Zhong Zheng, Wei Zhang |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Adult
Leiomyosarcoma Reoperation China medicine.medical_specialty medicine.medical_treatment Hysterectomy Young Adult Cox proportional hazards regression medicine Humans In patient Aged Neoplasm Staging Retrospective Studies Uterine leiomyosarcoma business.industry Significant difference Obstetrics and Gynecology Cancer Middle Aged Prognosis medicine.disease Surgery Reproductive Medicine Uterine Neoplasms Female Lymphadenectomy Sarcoma business |
| Zdroj: | Gynecologic and Obstetric Investigation. 86:408-414 |
| ISSN: | 1423-002X 0378-7346 |
| Popis: | Objective: The aim of this study was to evaluate the impact of initial surgical treatments and surgical re-exploration on the oncological outcomes of patients with incidentally diagnosed uterine leiomyosarcoma (uLMS). Design: A retrospective analysis of 87 patients who underwent re-exploration for incidentally diagnosed uLMS at the Fudan University Shanghai Cancer Center was performed. Methods: Kaplan-Meier and Cox proportional hazards regression models were used for analyses. Results: The median age (range) at diagnosis was 49 (23–76) years. The median disease-free survival (DFS) and overall survival (OS) were 15.1 and 56.7 months, respectively. The Kaplan-Meier curves and log-rank tests showed the median DFS was longer in patients with restaging operation (N = 30) than without (N = 55) (p = 0.017) but no significant difference in median OS (p = 0.142). In patients who underwent myomectomy/subtotal hysterectomy, 5 patients (28.5%) had remnant sarcoma during re-exploration with complete uterine removal, and re-exploration was associated with longer DFS (p = 0.038) and OS (p = 0.042). Limitations: The limitation of this study is its retrospective observational design with a limited number of patients. Conclusion: Reoperation with total hysterectomy after incomplete surgery may be helpful in patients with incidentally diagnosed uLMS at the first treatment. |
| Databáze: | OpenAIRE |
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