Pharmacokinetic and anti-colon cancer properties of curcumin-containing chitosan-pectinate composite nanoparticles
| Autor: | Kah Hay Yuen, You Zhuan Lee, Nashiru Billa, Clive J. Roberts, Enas Alkhader, Eng Kwong Seow, Rozita Rosli |
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| Rok vydání: | 2018 |
| Předmět: |
Male
Curcumin Colorectal cancer Cell Survival Biomedical Engineering Biophysics Bioengineering Antineoplastic Agents Apoptosis 02 engineering and technology Pharmacology Cell Line Biomaterials Chitosan Rats Sprague-Dawley 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Pharmacokinetics Drug Stability medicine Animals Humans Curcuma Active ingredient Drug Carriers biology 021001 nanoscience & nanotechnology medicine.disease biology.organism_classification Rhizome Drug Liberation chemistry 030220 oncology & carcinogenesis Colonic Neoplasms Nanoparticles Pectins Composite nanoparticles 0210 nano-technology |
| Zdroj: | Journal of biomaterials science. Polymer edition. 29(18) |
| ISSN: | 1568-5624 |
| Popis: | Curcumin, the active ingredient of the rhizome curcuma longa has been extensively studied as an anticancer agent for various types of tumours. However, its efficacy as an anticancer agent is restricted due to poor absorption from the gastrointestinal tract, rapid metabolism and degradation in acidic medium. In the present study, we encapsulated curcumin in chitosan-pectinate nanoparticulate system (CUR-CS-PEC-NPs) for deployment of curcumin to the colon, whereby curcumin is protected against degradative effects in the upper digestive tract, and hence, maintaining its anticancer properties until colon arrival. The CUR-CS-PEC-NPs was taken up by HT-29 colorectal cancer cells which ultimately resulted in a significant reduction in cancer cell propagation. The anti-proliferative effect of the encapsulated curcumin was similar to that of free curcumin at equivalent doses which confirms that the encapsulation process did not impede the anticancer activity of curcumin. The oral bioavailability (C |
| Databáze: | OpenAIRE |
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