Effect of ecdysterone on histamine release from rat peritoneal mast cells
| Autor: | Shorin Matsuo, Nobushige Nishimoto, Koichi Endo, Yoshinori Shiobara, Shun-Suke Inoue, Masao Takei |
|---|---|
| Rok vydání: | 1991 |
| Předmět: |
medicine.medical_specialty
Ecdysterone Pharmaceutical Science chemistry.chemical_element Biology Calcium Histamine Release chemistry.chemical_compound Internal medicine medicine Concanavalin A Animals Mast Cells Peritoneal Cavity Cells Cultured Immunoglobulin E Mast cell Antibodies Anti-Idiotypic Rats medicine.anatomical_structure Endocrinology Mechanism of action chemistry Cell culture biology.protein Liberation medicine.symptom Histamine |
| Zdroj: | Journal of pharmaceutical sciences. 80(4) |
| ISSN: | 0022-3549 |
| Popis: | Ecdysterone dose-dependently inhibited anti-lgE-induced histamine release from mast cells. Moreover, the rate and extent of histamine release from mast cells induced by Concanavalin A (Con A) are significantly diminished in samples incubated with ecdysterone. Ecdysterone inhibited both the initial and gradual rise in fluorescent response by anti-lgE and Con A. The effects of ecdysterone on the fluorescence response was correlated with the inhibition of histamine release. These results suggest the possibility that the inhibition of histamine release from rat mast cells by ecdysterone might be due to inhibition of Ca 2 + mobilization from intracellular Ca 2 + storage. |
| Databáze: | OpenAIRE |
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